ArticlePloS one2015
Longitudinal associations between physical and cognitive performance among community-dwelling older adults.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.Journal of the American Medical Directors Association · 2016Pooled it
- Frequent Karaoke Training Improves Frontal Executive Cognitive Skills, Tongue Pressure, and Respiratory Function in Elderly People: Pilot Study from a Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Effects of Gait Self-Efficacy and Lower-Extremity Physical Function on Dual-Task Performance in Older Adults.BioMed research international · 2017Trial
- Article
- Assessment of Bidirectional and Threshold-Response Associations Between Cognitive Function and Physical Performance: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Exploring the physical, mental, and social dimensions of middle-aged adults for active and healthy aging: A cross-sectional study.PloS one · 2025Article
- Functional training improves cognitive function, functional fitness, and BDNF levels in older women with mild cognitive impairment: a randomized controlled trial.Frontiers in physiology · 2025Article
- Cognitive impairment is a risk factor for decreased physical performance in the elderly.Heliyon · 2024Article
- Prediction Model for Cognitive Impairment among Disabled Older Adults: A Development and Validation Study.Healthcare (Basel, Switzerland) · 2024Article
- Do physical fitness and cognitive function mediate the relationship between basic activities of daily living and quality of life in older adults with dementia?Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Impact on physical function of the +AGIL Barcelona program in community-dwelling older adults with cognitive impairment: an interventional cohort study.BMC geriatrics · 2023Article
- Exploring cognitive trajectories and their association with physical performance: evidence from the China Health and Retirement Longitudinal Study.Epidemiology and health · 2023Article
- Cognitive impairment and low physical function among older Mexican Americans: findings from a 20-year follow-upAnnals of epidemiology · 2022Article
- The Brain Health Platform: Combining Resilience, Vulnerability, and Performance to Assess Brain Health and Risk of Alzheimer's Disease and Related Disorders.Journal of Alzheimer's disease : JAD · 2022Article
- How can dementia and disability be prevented in older adults: where are we today and where are we going?Journal of internal medicine · 2021Review
- A Virtual Reality-Based Screening Test for Cognitive Impairment in Small Vessel Disease.Journal of Alzheimer's disease reports · 2021Article
- Bidirectional associations between word memory and one-legged balance performance in mid and later life.Experimental gerontology · 2021Article
- A Modified CAIDE Risk Score as a Screening Tool for Cognitive Impairment in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Medical and Social Determinants of Brain Health and Dementia in a Multicultural Community Cohort of Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- The Resilience Index: A Quantifiable Measure of Brain Health and Risk of Cognitive Impairment and Dementia.Journal of Alzheimer's disease : JAD · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To assess the directionality of the association between physical and cognitive decline in later life, we compared patterns of decline in performance across groups defined by baseline presence of cognitive and/or physical impairment [none (n = 217); physical only (n = 169); cognitive only (n = 158), or both (n = 220)] in a large sample of participants in a cognitive aging study at the Knight Alzheimer's Disease Research Center at Washington University in St. Louis who were followed for up to 8 years (3,079 observations). Rates of decline reached 20% for physical performance and varied across cognitive tests (global, memory, speed, executive function, and visuospatial skills). We found that physical decline was better predicted by baseline cognitive impairment (slope = -1.22, p<0.001), with baseline physical impairment not contributing to further decline in physical performance (slope = -0.25, p = 0.294). In turn, baseline physical impairment was only marginally associated with rate of cognitive decline across various cognitive domains. The cognitive-functional association is likely to operate in the direction of cognitive impairment to physical decline although physical impairment may also play a role in cognitive decline/dementia. Interventions to prevent further functional decline and development of disability and complete dependence may benefit if targeted to individuals with cognitive impairment who are at increased risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.