ArticlePloS one2015
Changes in brain network efficiency and working memory performance in aging.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Application of Graph Theory for Identifying Connectivity Patterns in Human Brain Networks: A Systematic Review.Frontiers in neuroscience · 2019Pooled it
- Diurnal dynamics of multilayer brain networks predict cognitive trajectories in aging.GeroScience · 2026Article
- Associations between READ1 deletion, reading proficiency, and white matter network organisation in children with and without developmental dyslexia.Brain structure & function · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Resting-State and Task Functional Magnetic Resonance Imaging Network Topology Metrics With no Threshold Selection to Predict Cognition.Human brain mapping · 2026Article
- Article
- Effects of age in a cognitive-motor dual task: parametric manipulations of cognitive load and motor difficulty.Frontiers in human neuroscience · 2026Article
- Association between usage intensity of short video platforms and altered brain function: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Evaluating topological and graph-theoretical approaches to extract complex multimodal brain connectivity patterns in multiple sclerosis.Health information science and systems · 2025Article
- Sentence recall and neurophysiological effects of the "2-Sentence Problem" under time compression in younger and older listeners.Hearing research · 2025Article
- Dynamics of frontal cortex functional connectivity during cognitive tasks: insights from fNIRS analysis in the Dual n-back Paradigm.Cognitive processing · 2025Article
- Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer's disease.Science advances · 2025Article
- Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025Article
- Network segregation is associated with processing speed in the cognitively healthy oldest-old.eLife · 2025Article
- Time-varying brain state dynamics in trait impulsivity and anxiety: An HSMM analysis of resting-state fMRI.Social cognitive and affective neuroscience · 2025Article
- Longitudinal changes in brain connectivity correlate with neuropsychological testing in brain tumor resection patients.Frontiers in neuroscience · 2025Article
- Photobiomodulation mechanisms: duration of action in the human prefrontal cortex.Frontiers in behavioral neuroscience · 2025Article
- Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Hubs, influencers, and communities of executive functions: a task-based fMRI graph analysis.Frontiers in human neuroscience · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Working memory is a complex psychological construct referring to the temporary storage and active processing of information. We used functional connectivity brain network metrics quantifying local and global efficiency of information transfer for predicting individual variability in working memory performance on an n-back task in both young (n = 14) and older (n = 15) adults. Individual differences in both local and global efficiency during the working memory task were significant predictors of working memory performance in addition to age (and an interaction between age and global efficiency). Decreases in local efficiency during the working memory task were associated with better working memory performance in both age cohorts. In contrast, increases in global efficiency were associated with much better working performance for young participants; however, increases in global efficiency were associated with a slight decrease in working memory performance for older participants. Individual differences in local and global efficiency during resting-state sessions were not significant predictors of working memory performance. Significant group whole-brain functional network decreases in local efficiency also were observed during the working memory task compared to rest, whereas no significant differences were observed in network global efficiency. These results are discussed in relation to recently developed models of age-related differences in working memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.