ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2015
Effects of low-level carotid baroreflex stimulation on atrial electrophysiology.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- New approaches for treating atrial fibrillation: Focus on autonomic modulation.Trends in cardiovascular medicine · 2020Review
- Autonomic Modulation of Cardiac Arrhythmias: Methods to Assess Treatment and Outcomes.JACC. Clinical electrophysiology · 2020Review
- Carotid baroreceptor stimulation in obese rats affects white and brown adipose tissues differently in metabolic protection.Journal of lipid research · 2019Article
- Cardioprotective effects of low-level carotid baroreceptor stimulation against myocardial ischemia-reperfusion injury in canine model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to investigate the effects of low-level carotid baroreflex stimulation (LL-CBS) on atrial electrophysiology.
methodsIn protocol 1 (LL-CBS on physiological state), anesthetized rabbits were subjected to LL-CBS (n = 10) or surgical exposure (n = 6) for 1 h. In protocol 2 (LL-CBS on acute rapid atrial pacing), anesthetized rabbits underwent 3 h of rapid atrial pacing (RAP) with concomitant LL-CBS in the third hour (n = 7) or 3h-RAP without LL-CBS (n = 6). Carotid baroreceptor surrounded by electrodes allowed LL-CBS at 20 % below the voltage required to reduce systolic blood pressure or heart rate. Effective refractory period (ERP) and monophasic action potential duration (MAPD) were determined, and power spectral of heart rate variability (HRV) was analyzed at baseline as well as after interventions in all groups, respectively.
resultsIn protocol 1, LL-CBS significantly prolonged the ERPs, MAPD90, and MAPD50 and increased high-frequency (HF) HRV component but it decreased low-frequency (LF) HRV component and LF/HF ratio. In protocol 2, 3h-RAP significantly shortened ERPs, MAPD90, and MAPD50 and decreased HF but it increased LF and LF/HF ratio. However, LL-CBS reversed the variations caused by RAP.
conclusionsLL-CBS prolongs ERPs and MAPD of the left atrium and attenuates RAP-induced atrial electrical remodeling including the shortening of ERPs and MAPD, probably by modulating the autonomic nervous system.
Indexed as
Identifiers
25874720What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.