ArticlePloS one2015
Bistability: requirements on cell-volume, protein diffusion, and thermodynamics.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Compartmental exchange regulates steady states and stochastic switching of a phosphorylation network.Biophysical journal · 2024Article
- Decorating the surface of Escherichia coli with bacterial lipoproteins: a comparative analysis of different display systems.Microbial cell factories · 2021Article
- Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry.Molecular biology of the cell · 2021Article
- Entropy production selects nonequilibrium states in multistable systems.Scientific reports · 2017Article
- A minimal model of burst-noise induced bistability.PloS one · 2017Article
- Effects of cell cycle noise on excitable gene circuits.Physical biology · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Bistability is considered wide-spread among bacteria and eukaryotic cells, useful, e.g., for enzyme induction, bet hedging, and epigenetic switching. However, this phenomenon has mostly been described with deterministic dynamic or well-mixed stochastic models. Here, we map known biological bistable systems onto the well-characterized biochemical Schlögl model, using analytical calculations and stochastic spatiotemporal simulations. In addition to network architecture and strong thermodynamic driving away from equilibrium, we show that bistability requires fine-tuning towards small cell volumes (or compartments) and fast protein diffusion (well mixing). Bistability is thus fragile and hence may be restricted to small bacteria and eukaryotic nuclei, with switching triggered by volume changes during the cell cycle. For large volumes, single cells generally loose their ability for bistable switching and instead undergo a first-order phase transition.
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Registered trials
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