ArticlePharmaceutical research2015
Salt Stability - The Effect of pHmax on Salt to Free Base Conversion.
Article in Pharmaceutical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Pharmaceutical Salts: Comprehensive Insights From Fundamental Chemistry to FDA Approvals (2019-2023).AAPS PharmSciTech · 2025Review
- Influence of Crystal Disorder on the Forced Oxidative Degradation of Vortioxetine HBr.AAPS PharmSciTech · 2023Article
- Dissolution Profiles of Poorly Soluble Drug Salts in Bicarbonate Buffer.Pharmaceutical research · 2023Article
- Developing In Situ Chemometric Models with Raman Spectroscopy for Monitoring an API Disproportionation with a Complex Polymorphic Landscape.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Synthesis, Characterization, and Stability Assessment for the Benzoate, Hydrochloride, Malonate, and Nicotinate Salts of Bedaquiline.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug.Crystal growth & design · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to investigate how the disproportionation process can be impacted by the properties of the salt, specifically pHmax.
methodsFive miconazole salts and four sertraline salts were selected for this study. The extent of conversion was quantified using Raman spectroscopy. A mathematical model was utilized to estimate the theoretical amount of conversion.
resultsA trend was observed that for a given series of salts of a particular basic compound (both sertraline and miconazole are bases), the extent of disproportionation increases as pHmax decreases. Miconazole phosphate monohydrate and sertraline mesylate, although exhibiting significantly different pHmax values (more than 2 units apart), underwent a similar extent of disproportionation, which may be attributed to the lower buffering capacity of sertraline salts.
conclusionThis work shows that the disproportionation tendency can be influenced by pHmax and buffering capacity and thus highlights the importance of selecting the appropriate salt form during the screening process in order to avoid salt-to-free form conversion.
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Registered trials
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