ArticlePloS one2015
The impact of diabetes mellitus and corresponding HbA1c levels on the future risks of cardiovascular disease and mortality: a representative cohort study in Taiwan.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 7 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Evidence-based recommendations for the use of continuous glucose monitoring in type 2 diabetes: the Italian guidelines.Acta diabetologica · 2026Guideline
- Point-of-care testing for non-communicable diseases and health literacy outcomes: a systematic review.BMC public health · 2026Pooled it
- Pooled it
- Effect of Different Glucose Monitoring Methods on Bold Glucose Control: A Systematic Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomes in hypertensive patients: a meta-analysis.International urology and nephrology · 2018Pooled it
- Relationship Between Glycated Hemoglobin and Stroke Risk: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2018Pooled it
- The Use of Exenatide in Managing Markers of Cardiovascular Risk in Patients with Type 2 Diabetes: A Systematic Review.International journal of environmental research and public health · 2016Pooled it
- Exploring insulin rejection through photo-elicitation among informal caregivers and patients with type 2 diabetes mellitus.Korean journal of family medicine · 2026Article
- Impact of early and tight HbA1c control on the risk of long-term complications and cardiovascular death in patients with type 2 diabetes from the Swedish National Diabetes Register.Diabetes, obesity & metabolism · 2026Article
- Determinants of Poor Glycemic Control in Type 2 Diabetes Patients With Coronary Artery Disease: A Case-Control Study.Health science reports · 2026Article
- Risk of major adverse cardiovascular events and all-cause mortality in type 2 diabetic patients receiving insulin versus non-insulin treatment intensification.Scientific reports · 2025Article
- Low-moderate alcohol use effects on glycemic control of patients presenting in the ED.International journal of emergency medicine · 2025Article
- Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project.Cardiovascular diabetology · 2025Article
- Article
- Association between glycated hemoglobin and risk of all-cause mortality in community patients with type 2 diabetes: A prospective cohort study.Journal of diabetes investigation · 2024Article
- External validation of a cardiovascular risk model for Omani patients with type 2 diabetes mellitus: a retrospective cohort study.BMJ open · 2023Article
- Adjusting the Use of Glucose-Lowering Agents in the Real-World Clinical Management of People with Type 2 Diabetes: A Narrative Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Review
- The Patient's Physiological Status at the Start Determines the Success of the Inpatient Cardiovascular Rehabilitation Program.Journal of clinical medicine · 2023Article
- Association betweenJournal of nutritional science · 2023Article
- Is Lower Better?: HbA1c Level Is Associated With Venous Graft Patency Following Coronary Bypass Surgery.JACC. Asia · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study explored the relationship between the glycated hemoglobin (HbA1c) level in patients with or without diabetes mellitus and future risks of cardiovascular disease and death.
methodsBased on a national representative cohort, a total of 5277 participants (7% with diabetes) were selected from Taiwan's Triple High Survey in 2002. The comorbidities, medication usages, and outcomes of cardiovascular disease and death, were extracted from the Taiwan's National Health Insurance Research Database and National Death Registry.
resultsAfter a median follow-up of 9.7 years, participants with diabetes had higher incidence of new onset cardiovascular disease (17.9 versus 3.16 cases per 1000 person-years) and death (20.1 versus 4.96 cases per 1000 person-years) than those without diabetes (all P < 0.001). Diabetes showed increased risk of all-cause death after adjusting for all confounders (adjusted hazard ratio [HR]: 2.29, 95% confidence interval [CI]: 1.52-3.45). Every 1% increment of HbA1c was positively associated with the risk of total cardiovascular disease (HR: 1.2, 95% CI: 1.08-1.34) and the risk of death (HR: 1.14, 95% CI: 1.03-1.26) for all participants. As compared to the reference group with HbA1c below 5.5%, participants with HbA1c levels ≥7.5% had significantly elevated future risks of total cardiovascular disease (HR: 1.82, 95% CI: 1.01-3.26) and all-cause death (HR: 2.45, 95% CI: 1.45-4.14). CONCLUSIONS/
interpretationElevated HbA1C levels were associated with increased risks of cardiovascular disease and death, the suboptimal glycemic control with HbA1c level over 7.5% (58.5 mmol/mol) was strongly associated with increased risks of cardiovascular disease and all-cause death.
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