ArticlePloS one2015
Platelet parameters and (1, 3)-β-D-glucan as a diagnostic and prognostic marker of invasive fungal disease in preterm infants.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Assistive diagnostic indicators for infections related to lumbar posterior interbody fusion internal fixation: platelet count and mean platelet volume.Journal of orthopaedic surgery and research · 2023Article
- Congenital candidiasis in a full-term infant: A case report.The Journal of international medical research · 2023Article
- Serum Beta-D-Glucan in the Diagnosis of Invasive Fungal Disease in Neonates, Children and Adolescents: A Critical Analysis of Current Data.Journal of fungi (Basel, Switzerland) · 2022Review
- Article
- Predictors for oesophageal candidiasis in patients with liver cirrhosis.Le infezioni in medicina · 2022Article
- Combination value of biomarkers in discriminating adult onset Still's disease and sepsis.Wiener klinische Wochenschrift · 2021Article
- Prophylactic Use of Fluconazole in Very Premature Infants.Frontiers in pediatrics · 2021Article
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Article
- Article
- Article
- The diagnostic value of (1,3)-β-D-glucan alone or combined with traditional inflammatory markers in neonatal invasive candidiasis.BMC infectious diseases · 2019Article
- A routine blood test-associated predictive model and application for tuberculosis diagnosis: a retrospective cohort study from northwest China.The Journal of international medical research · 2019Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- The association between platelet indices and deep surgical site infection after open induction internal fixation for traumatic limb fractures.Infection and drug resistance · 2018Article
- Protective Effect of Citrulline on the Hearts of Rats with Sepsis Induced by Cecal Ligation and Puncture.BioMed research international · 2018Article
- Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.Journal of the Pediatric Infectious Diseases Society · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis of neonatal invasive fungal disease (IFD) is difficult and often delayed. The platelet parameters and (1, 3)-β-D-Glucan (BG) may be useful for diagnosing IFD, but their diagnostic performance are not well characterized in neonates. We studied 63 preterm infants with IFD, 160 preterm infants without sepsis (preterm control), and 41 preterm infants with bacterial sepsis. Platelet parameters at the first day of onset of IFD and at the fourteenth day after antifungal treatment were evaluated. Serum BG was measured. Platelet count (PC), plateletcrit (PCT), and platelet distribution width (PDW) values were significantly lower, and mean platelet volume (MPV) values significantly higher in the IFD versus preterm control infants. PC and PCT values were much lower in infants with IFD versus bacterial sepsis, and there were significant differences in BG value between the two groups. After 14 days of antifungal treatment, significant elevations in PC, PCT, PDW and reductions in MPV levels in IFD group were observed. Receiver operating characteristic (ROC) curves showed that PC and PCT were strong predictors of IFD. The PC and PCT cut-offs for predicting IFD were 119.5 (sensitivity 78%, specificity 95%) and 0.21 (sensitivity 83%, specificity 85%), respectively. There were significant differences in PC and PCT levels between deceased and survived patients. The PC and PCT cut-offs for predicting deceased IFD were 39 (sensitivity 62%, specificity 86%) and 0.04 (sensitivity 50%, specificity 95%), respectively. The sensitivity in diagnosing IFD by a BG cutoff of ≥10 pg/ml was 68.3% and specificity was 75.6%. PC and PCT levels in the BG ≥400 pg/ml group were significantly lower compared to the BG<400 pg/ml group. Platelet parameters and BG could be useful biomarkers for the diagnosis and prognosis of neonatal IFD.
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