Observational studyKorean journal of urology2015
Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men.
Observational study in Korean journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The Effects of Testosterone Supplementation on Cognitive Functioning in Older Men.CNS & neurological disorders drug targets · 2016Trial
- The British Society for Sexual Medicine Guidelines on Male Adult Testosterone Deficiency, with Statements for Practice.The world journal of men's health · 2023Review
- Metabolic effects of dopamine agonists in patients with prolactinomas: a systematic review and meta-analysis.Endocrine connections · 2019Article
- Erectile dysfunction among patients with chronic brucellosis.International journal of impotence research · 2018Article
- Which Exercise Is Better for Increasing Serum Testosterone Levels in Patients with Erectile Dysfunction?The world journal of men's health · 2018Article
- UK policy statements on testosterone deficiency.International journal of clinical practice · 2017Article
- An update on the role of testosterone replacement therapy in the management of hypogonadism.Therapeutic advances in urology · 2016Review
- Testosterone Replacement Therapy and Mortality in Older Men.Drug safety · 2016Review
- Effects of long-term treatment with testosterone on weight and waist size in 411 hypogonadal men with obesity classes I-III: observational data from two registry studies.International journal of obesity (2005) · 2016Observational
- Testosterone replacement therapy: Dilemmas and challenges in China and Asia.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the potential benefits of testosterone administration to elderly men (>65 years) with late-onset hypogonadism (LOH) in comparison with younger men and to assess the safety of testosterone administration to elderly men. MATERIALS AND
methodsA total of 561 hypogonadal men from two registry studies were divided into age groups of ≤65 years (group Y, n=450; range, 32-65 years) and >65 years (group O, n=111; range, 66-84 years). Following an initial 6-week interval, all men were treated with 3-month injections of parenteral testosterone undecanoate for up to 6 years.
resultsOver the 6 years, there was a progressive decrease of body weight and waist circumference. Beneficial effects on lipids and other metabolic factors and on psychological and sexual functioning progressed over the first 24 to 42 months and were sustained. Rather than a deterioration, there was an improvement of urinary parameters. Prostate volume and prostate-specific antigen increased moderately. Hematocrit levels increased but remained within safe margins.
conclusionsThe benefits of restoring serum testosterone in men with LOH were not significantly different between men older than 65 years of age and younger men. There were no indications that side effects were more severe in elderly men. The effects on prostate and urinary function and hematocrit were within safe margins. Age itself need not be a contraindication to testosterone treatment of elderly men with LOH.
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