ArticleToxicological research2015
Improved Therapeutic Profiles of PLA2-Free Bee Venom Prepared by Ultrafiltration Method.
Article in Toxicological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 24 citations in OpenAlex.
- Changes in Lipid Profile of Keratinocytes from Rat Skin Exposed to Chronic UVA or UVB Radiation and Topical Application of Cannabidiol.Antioxidants (Basel, Switzerland) · 2020Article
- Inhibitory effects of skate cartilage chondroitin sulfate-rich extract on the production of inflammatory mediators and ROS in lipopolysaccharide-treated murine macrophages: a comparison with shark cartilage chondroitin sulfate.In vitro cellular & developmental biology. Animal · 2020Article
- Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish.Biomolecules & therapeutics · 2018Article
- Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway.Biomolecules & therapeutics · 2017Article
- The Immunomodulatory Activity of Mori folium, the Leaf ofJournal of cancer prevention · 2016Article
- Article
- Evaluation of Phototoxic and Skin Sensitization Potentials of PLA 2 -Free Bee Venom.Evidence-based complementary and alternative medicine : eCAM · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bee venom (BV) has long been used in traditional Eastern and Western medicine for chronic inflammation, pain and skin therapy. Human exposure to BV, however, often causes unwanted adverse effects and is even fatal in some cases. Phospholipase A2 (PLA2) of BV is now suspected to play a key role in these adverse effects. We investigated the potential use of PLA2-free bee venom (PBV) as a replacement for BV in cosmetic products. PBV prepared by molecular weight cut-off ultrafiltration exhibits a superior profile in comparison with regular BV, by inhibiting elastase activity and suppressing the induction of nitric oxide (NO) and metalloproteinase-9 (MMP-9), while retaining the effects of cell proliferation and protection against ultraviolet B (UVB)-induced damage in human dermal fibroblast cells. PBV thus appears to be more promising than BV as a cosmetic ingredient with a reduced potential for adverse reactions in the recipient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.