ReviewToxicological research2015
Influence of toxicologically relevant metals on human epigenetic regulation.
Review in Toxicological research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- Integrated Biochemical and Ultrastructural Responses ofPlants (Basel, Switzerland) · 2026Article
- Metal Ion-Mediated Regulation of Cell Fate: A Novel Strategy for Synergy with Radiotherapy and Immunotherapy.Cancers · 2026Review
- The role of the gut microbiome in the associations between lead exposure and child neurodevelopment.Toxicology letters · 2025Review
- Review
- The association between toenail metals and extracellular MicroRNAs (ex-miRNAs) among the participants of the Normative Aging study (NAS).Environmental research · 2024Article
- Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential.Plants (Basel, Switzerland) · 2024Review
- Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish.The Science of the total environment · 2024Article
- Plants' molecular behavior to heavy metals: from criticality to toxicity.Frontiers in plant science · 2024Review
- Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm.Chemosphere · 2023Article
- Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities.Frontiers in molecular biosciences · 2023Review
- Metals Exposures and DNA Methylation: Current Evidence and Future Directions.Current environmental health reports · 2022Review
- Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.Nature reviews. Neurology · 2022Review
- Cisplatin, environmental metals, and cardiovascular disease: an urgent need to understand underlying mechanisms.Cardio-oncology (London, England) · 2021Article
- Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure.Scientific reports · 2021Article
- Transcriptional Analyses of Acute Exposure to Methylmercury on Erythrocytes of Loggerhead Sea Turtle.Toxics · 2021Article
- Hallmarks of environmental insults.Cell · 2021Review
- Ethnic Differences of Urinary Cadmium in Cigarette Smokers from the Multiethnic Cohort Study.International journal of environmental research and public health · 2021Article
- Exposure to cadmium and copper triggers cytotoxic effects and epigenetic changes in human colorectal carcinoma HT-29 cells.Experimental and therapeutic medicine · 2021Article
- Epigenetic influence of environmentally neurotoxic metals.Neurotoxicology · 2020Review
- Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental toxicants such as toxic metals can alter epigenetic regulatory features such as DNA methylation, histone modification, and non-coding RNA expression. Heavy metals influence gene expression by epigenetic mechanisms and by directly binding to various metal response elements in the target gene promoters. Given the role of epigenetic alterations in regulating genes, there is potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. Here, we focus on recent advances in understanding epigenetic changes, gene expression, and biological effects induced by toxic metals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.