ReviewInternational journal of endocrinology2015
The endocrine role of estrogens on human male skeleton.
Review in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Testosterone supplementation and bone parameters: a systematic review and meta-analysis study.Journal of endocrinological investigation · 2022Pooled it
- Near Final Height in Males treated with Aromatase InhibitorsJournal of clinical research in pediatric endocrinology · 2026Article
- Too late, too often: missed opportunities in male bone health: a real-world portrait from a 14-year specialist referral experience.Journal of endocrinological investigation · 2026Observational
- Aromatase inhibitors as a therapeutic strategy for male prolactinoma resistant to dopamine agonists: a retrospective cohort study and literature review.Journal of endocrinological investigation · 2024Review
- Association between sex hormones and bone age in boys aged 9-18 years from China.Journal of cellular and molecular medicine · 2024Article
- Advantage of ostarine over raloxifene and their combined treatments for muscle of estrogen-deficient rats.Journal of endocrinological investigation · 2024Article
- Bone quality in endocrine diseases: determinants and clinical relevance.Journal of endocrinological investigation · 2023Review
- Reversibility in male idiopathic osteoporosis possible.Endocrinology, diabetes & metabolism case reports · 2023Article
- Association between phthalate exposure and accelerated bone maturation in Chinese girls with early puberty onset: a propensity score-matched case-control analysis.Scientific reports · 2022Article
- Anastrozole as add-on therapy for cabergoline-resistant prolactin-secreting pituitary adenomas: real-life experience in male patients.Pituitary · 2021Article
- Regional and ethnic differences in semen quality and reproductive hormones in Russia: A Siberian population-based cohort study of young men.Andrology · 2021Article
- Developmental morphology of the cervical vertebrae and the emergence of sexual dimorphism in size and shape: A computed tomography study.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Article
- Bone Health in Aging Men: Does Zinc and Cuprum Level Matter?Biomolecules · 2021Article
- Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.Frontiers in endocrinology · 2020Article
- CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.Life science alliance · 2019Article
- ERβ compensates for the absence of ERα function to promote osteoblast viability by inhibition of SOST signaling.Experimental and therapeutic medicine · 2017Article
- Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen-nanodiamond hydrogel.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Aging and sex hormones in males.Virulence · 2017Review
- Estrogens in Male Physiology.Physiological reviews · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Before the characterization of human and animal models of estrogen deficiency, estrogen action was confined in the context of the female bone. These interesting models uncovered a wide spectrum of unexpected estrogen actions on bone in males, allowing the formulation of an estrogen-centric theory useful to explain how sex steroids act on bone in men. Most of the principal physiological events that take place in the developing and mature male bone are now considered to be under the control of estrogen. Estrogen determines the acceleration of bone elongation at puberty, epiphyseal closure, harmonic skeletal proportions, the achievement of peak bone mass, and the maintenance of bone mass. Furthermore, it seems to crosstalk with androgen even in the determination of bone size, a more androgen-dependent phenomenon. At puberty, epiphyseal closure and growth arrest occur when a critical number of estrogens is reached. The same mechanism based on a critical threshold of serum estradiol seems to operate in men during adulthood for bone mass maintenance via the modulation of bone formation and resorption in men. This threshold should be better identified in-between the ranges of 15 and 25 pg/mL. Future basic and clinical research will optimize strategies for the management of bone diseases related to estrogen deficiency in men.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.