ArticleFrontiers in behavioral neuroscience2015
Two dopamine receptors play different roles in phase change of the migratory locust.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A systematic review of locust phase polyphenism: from proximate mechanisms to ecology and management.PeerJ · 2026Pooled it
- The Integrative Imperatives of Locust Phase Polyphenism Research: A Bibliometric Analysis.Integrative organismal biology (Oxford, England) · 2026Review
- Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (Evolutionary applications · 2025Article
- Phonotaxis in Male Field Crickets: The Role of Flight Experience, Serotonin and Octopamine Neurotransmission.Insects · 2025Article
- Juvenile responses to immune challenges are not carried through to subsequent life stages in an insect.Scientific reports · 2024Article
- MicroRNA ame-let-7 targets Amdop2 to increase sucrose sensitivity in honey bees (Apis mellifera).Frontiers in zoology · 2023Article
- 4-Vinylanisole promotes conspecific interaction and acquisition of gregarious behavior in the migratory locust.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- An odorant binding protein is involved in counteracting detection-avoidance and Toll-pathway innate immunity.Journal of advanced research · 2023Article
- Dopamine mediates the pea aphid wing plasticity.Biology letters · 2023Article
- Review
- Glutamate-GABA imbalance mediated by miR-8-5p and its STTM regulates phase-related behavior of locusts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The time course of behavioural phase change in the Central American locust Schistocerca piceifrons.The Journal of experimental biology · 2022Article
- Article
- Sulfation modification of dopamine in brain regulates aggregative behavior of animals.National science review · 2022Article
- Parasitoid wasp venom manipulates host innate behavior via subtype-specific dopamine receptor activation.The Journal of experimental biology · 2022Article
- Genome-Wide Identification of Neuropeptides and Their Receptors in an Aphid Endoparasitoid Wasp,Insects · 2021Article
- Effects of miR-143 and its target receptor 5-HT2B on agonistic behavior in the Chinese mitten crab (Eriocheir sinensis).Scientific reports · 2021Article
- Phase-related differences in egg production of the migratory locust regulated by differential oosorption through microRNA-34 targeting activinβ.PLoS genetics · 2021Article
- Long noncoding RNA PAHAL modulates locust behavioural plasticity through the feedback regulation of dopamine biosynthesis.PLoS genetics · 2020Article
- Juvenile hormone suppresses aggregation behavior through influencing antennal gene expression in locusts.PLoS genetics · 2020Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The migratory locust, Locusta migratoria, shows remarkable phenotypic plasticity at behavioral, physiological, and morphological levels in response to fluctuation in population density. Our previous studies demonstrated that dopamine (DA) and the genes in the dopamine metabolic pathway mediate phase change in Locusta. However, the functions of different dopamine receptors in modulating locust phase change have not been fully explored. In the present study, DA concentration in the brain increased during crowding and decreased during isolation. The expression level of dopamine receptor 1 (Dop1) increased from 1 to 4 h of crowding, but remained unchanged during isolation. Injection of Dop1 agonist SKF38393 into the brains of solitary locusts promoted gregarization, induced conspecific attraction-response and increased locomotion. RNAi knockdown of Dop1 and injection of antagonist SCH23390 in gregarious locusts induced solitary behavior, promoted the shift to repulsion-response and reduced locomotion. By contrast, the expression level of dopamine receptor 2 (Dop2) gradually increased during isolation, but remained stable during crowding. During the isolation of gregarious locusts, injection of Dop2 antagonist S(-)-sulpiride or RNAi knockdown of Dop2 inhibited solitarization, maintained conspecific attraction-response and increased locomotion; by comparison, the isolated controls displayed conspecific repulsion-response and weaker motility. Activation of Dop2 in solitary locusts through injection of agonist, R(-)-TNPA, did not affect their behavioral state. Thus, DA-Dop1 signaling in the brain of Locusta induced the gregariousness, whereas DA-Dop2 signaling mediated the solitariness. Our study demonstrated that Dop1 and Dop2 modulated locust phase change in two different directions. Further investigation of Locusta Dop1 and Dop2 functions in modulating phase change will improve our understanding of the molecular mechanism underlying phenotypic plasticity in locusts.
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