ArticleFrontiers in systems neuroscience2015
Augmented brain function by coordinated reset stimulation with slowly varying sequences.
Article in Frontiers in systems neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections.Frontiers in network physiology · 2024Article
- Preliminary Experience with a Four-Lead Implantable Pulse Generator for Deep Brain Stimulation.Stereotactic and functional neurosurgery · 2023Article
- Synaptic network structure shapes cortically evoked spatio-temporal responses of STN and GPe neurons in a computational model.Frontiers in neuroinformatics · 2023Article
- Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli.PLoS computational biology · 2022Article
- Long-Lasting Desynchronization of Plastic Neuronal Networks by Double-Random Coordinated Reset Stimulation.Frontiers in network physiology · 2022Article
- Shuffling Improves the Acute and Carryover Effect of Subthalamic Coordinated Reset Deep Brain Stimulation.Frontiers in neurology · 2022Article
- Long-Lasting Desynchronization Effects of Coordinated Reset Stimulation Improved by Random Jitters.Frontiers in physiology · 2021Article
- Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson's Disease.Frontiers in physiology · 2021Article
- Long-Lasting Desynchronization of Plastic Neural Networks by Random Reset Stimulation.Frontiers in physiology · 2020Article
- Acoustic coordinated reset therapy for tinnitus with perceptually relevant frequency spacing and levels.Scientific reports · 2019Article
- The Evolution of Neuromodulation in the Treatment of Chronic Pain: Forward-Looking Perspectives.Pain medicine (Malden, Mass.) · 2019Review
- Deep Brain Stimulation Programming 2.0: Future Perspectives for Target Identification and Adaptive Closed Loop Stimulation.Frontiers in neurology · 2019Review
- Controlling Synchronization of Spiking Neuronal Networks by Harnessing Synaptic Plasticity.Frontiers in computational neuroscience · 2019Article
- Delay-Induced Multistability and Loop Formation in Neuronal Networks with Spike-Timing-Dependent Plasticity.Scientific reports · 2018Article
- How stimulation frequency and intensity impact on the long-lasting effects of coordinated reset stimulation.PLoS computational biology · 2018Article
- Review
- Computationally Developed Sham Stimulation Protocol for Multichannel Desynchronizing Stimulation.Frontiers in physiology · 2018Article
- Periodic flashing coordinated reset stimulation paradigm reduces sensitivity to ON and OFF period durations.PloS one · 2018Article
- Short-Term Dosage Regimen for Stimulation-Induced Long-Lasting Desynchronization.Frontiers in physiology · 2018Article
- Coordinated reset vibrotactile stimulation shows prolonged improvement in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several brain disorders are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR) stimulation was developed to selectively counteract abnormal neuronal synchrony by desynchronization. For this, phase resetting stimuli are delivered to different subpopulations in a timely coordinated way. In neural networks with spike timing-dependent plasticity CR stimulation may eventually lead to an anti-kindling, i.e., an unlearning of abnormal synaptic connectivity and abnormal synchrony. The spatiotemporal sequence by which all stimulation sites are stimulated exactly once is called the stimulation site sequence, or briefly sequence. So far, in simulations, pre-clinical and clinical applications CR was applied either with fixed sequences or rapidly varying sequences (RVS). In this computational study we show that appropriate repetition of the sequence with occasional random switching to the next sequence may significantly improve the anti-kindling effect of CR. To this end, a sequence is applied many times before randomly switching to the next sequence. This new method is called SVS CR stimulation, i.e., CR with slowly varying sequences. In a neuronal network with strong short-range excitatory and weak long-range inhibitory dynamic couplings SVS CR stimulation turns out to be superior to CR stimulation with fixed sequences or RVS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.