ReviewFrontiers in neuroscience2015
Environmental insults in early life and submissiveness later in life in mouse models.
Review in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Operant House: A versatile open-source platform for automated operant conditioning testing of mice in home cages.PloS one · 2026Article
- In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.Nature neuroscience · 2025Article
- Stress in the social context: a behavioural and eco-evolutionary perspective.The Journal of experimental biology · 2023Review
- Wound inflammation post-orchiectomy affects the social dynamic of Nelore bulls.BMC veterinary research · 2023Article
- Neuroprotective Effects of Ceftriaxone Involve the Reduction of Aβ Burden and Neuroinflammatory Response in a Mouse Model of Alzheimer's Disease.Frontiers in neuroscience · 2021Article
- Social subordination induced by early life adversity rewires inhibitory control of the prefrontal cortex via enhanced Npy1r signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.Journal of neuroscience methods · 2018Article
- Developmental stress and social phenotypes: integrating neuroendocrine, behavioural and evolutionary perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Effects of early life adversity and sex on dominance in European starlings.Animal behaviour · 2017Article
- Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dominant and subordinate dispositions are not only determined genetically but also nurtured by environmental stimuli during neuroendocrine development. However, the relationship between early life environment and dominance behavior remains elusive. Using the IntelliCage-based competition task for group-housed mice, we have previously described two cases in which environmental insults during the developmental period altered the outcome of dominance behavior later in life. First, mice that were repeatedly isolated from their mother and their littermates (early deprivation; ED), and second, mice perinatally exposed to an environmental pollutant, dioxin, both exhibited subordinate phenotypes, defined by decreased occupancy of limited resource sites under highly competitive circumstances. Similar alterations found in the cortex and limbic area of these two models are suggestive of the presence of neural systems shared across generalized dominance behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.