Evidence map›Paper›PMID 25873770›Full record

ReviewMediators of inflammation2015

Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder.

Xiujuan Wu, Wei Wu, Wei Pan, Limin Wu, Kangding Liu, Hong-Liang Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 3 syntheses or guidelines pooled it, 218 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Case Report: long-term clinical outcomes inFrontiers in pharmacology · 2025
    Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xiujuan WuNeuroscience Center, Department of Neurology, the First Hospital of Jilin University, Jilin University, Xinmin Street No. 71, Changchun 130021, China.
Wei WuDepartment of Neurovascular Surgery, the First Hospital of Jilin University, Jilin University, Xinmin Street No. 71, Changchun 130021, China.
Wei PanSchool of Public Health, Jilin University, Xinmin Street No. 1163, Changchun 130021, China.
Limin WuNeuroscience Center, Department of Neurology, the First Hospital of Jilin University, Jilin University, Xinmin Street No. 71, Changchun 130021, China ; Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Kangding LiuNeuroscience Center, Department of Neurology, the First Hospital of Jilin University, Jilin University, Xinmin Street No. 71, Changchun 130021, China.
Hong-Liang ZhangNeuroscience Center, Department of Neurology, the First Hospital of Jilin University, Jilin University, Xinmin Street No. 71, Changchun 130021, China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration. However, the causal relationship between viral infections and ANE and the exact pathogenesis of ANE remain unclear; both environmental and host factors might be involved. Most cases of ANE are sporadic and nonrecurrent, namely, isolated or sporadic ANE; however, few cases are recurrent and with familial episodes. The recurrent and familial forms of ANE were found to be incompletely autosomal-dominant. Further the missense mutations in the gene encoding the nuclear pore protein Ran Binding Protein 2 (RANBP2) were identified. Although the clinical course and the prognosis of ANE are diverse, the hallmark of neuroradiologic manifestation of ANE is multifocal symmetric brain lesions which are demonstrated by computed tomography (CT) or magnetic resonance imaging (MRI). The treatment of ANE is still under investigation. We summarize the up-to-date knowledge on ANE, with emphasis on prompt diagnosis and better treatment of this rare but fatal disease.

Indexed as

Acute DiseaseBrain DiseasesHumansMagnetic Resonance ImagingNecrosisPrognosisReceptor, EphB2Tomography, X-Ray ComputedEPHB2 protein, humanReceptor, EphB2

Identifiers

PMID25873770
PMCPMC4385702
OpenAlexW2028711067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.