ReviewProceedings of the Japan Academy. Series B, Physical and biological sciences2006
Genetic basis for the lack of N-glycolylneuraminic acid expression in human tissues and its implication to human evolution.
Review in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Sialidases as Potential Therapeutic Targets for Treatment of a Number of Human Diseases.International journal of molecular sciences · 2025Review
- SerumBiomolecules · 2024Article
- The Ying and Yang of Ganglioside Function in Cancer.Cancers · 2023Review
- Characterization of N-glycome profile in mouse brain tissue regions by MALDI-TOF/MS.Analytical and bioanalytical chemistry · 2023Article
- Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids.Glycobiology · 2022Article
- Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.Nature communications · 2022Article
- Intestine specific regulation of pig cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis.Scientific reports · 2019Article
- The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.Trends in biochemical sciences · 2016Review
- Transcriptome profiling of bovine milk oligosaccharide metabolism genes using RNA-sequencing.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sialic acid is a family of acidic monosaccharides and consists of over 30 derivatives. Two major derivatives are N-acetylneuraminic acid (NeuAc) and N-glycolylneuraminic acid (NeuGc), and the hydroxylation of CMP-NeuAc is the rate limiting reaction for the production of NeuGc. The hydroxylation was carried out by a complex formed with hydroxylase, cytochrome b5, and NADH-cytochrome b5 reductase. Mouse hydroxylase was purified from the cytosolic fraction of the liver and its cDNA was cloned. Normal human tissues do not contain NeuGc. Human hydroxylase cDNA was also cloned and the sequence revealed that human hydroxylase has 92 bp deletion. The deletion is the cause of defective expression of NeuGc in human. Chimpanzee has intact hydroxylase gene and the 92 bp deletion occurred after the divergence of human ancestor from chimpanzee ancestor. Biochemical and molecular biological studies on the biosynthesis of NeuGc and biological functions of NeuGc are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.