ArticleGenetics2015
Cortical Folding of the Primate Brain: An Interdisciplinary Examination of the Genetic Architecture, Modularity, and Evolvability of a Significant Neurological Trait in Pedigreed Baboons (Genus Papio).
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Bidirectional cortical gyrification alterations in chronic obstructive pulmonary disease: links to cognitive impairment and global initiative for chronic obstructive lung disease staging.BMC medical imaging · 2026Article
- Heritability of gray matter volume and asymmetry in chimpanzees (Pan troglodytes) and their association to cognitive abilities and tool use.Brain structure & function · 2025Article
- Article
- Planum Temporale Asymmetries in Primates: A Comparative Study in Great Apes and Monkeys.American journal of biological anthropology · 2025Article
- Article
- Prenatal environmental exposures and brain development: studies with baboons and other nonhuman primates.Advances in drug and alcohol research · 2025Review
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation.Neurobiology of aging · 2023Article
- A novel morphometric signature of brain alterations in type 2 diabetes: Patterns of changed cortical gyrification.The European journal of neuroscience · 2021Article
- Common functional localizers to enhance NHP & cross-species neuroscience imaging research.NeuroImage · 2021Article
- The reliability and heritability of cortical folds and their genetic correlations across hemispheres.Communications biology · 2020Article
- Reproducibility of leftward planum temporale asymmetries in two genetically isolated populations of chimpanzees (Proceedings. Biological sciences · 2020Article
- Greater variability in chimpanzee (Proceedings. Biological sciences · 2020Article
- Structural alterations in patients with obsessive-compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness.Journal of psychiatry & neuroscience : JPN · 2017Article
- Premature Brain Aging in Baboons Resulting from Moderate Fetal Undernutrition.Frontiers in aging neuroscience · 2017Article
- Evolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.Evolution; international journal of organic evolution · 2016Article
- Relaxed genetic control of cortical organization in human brains compared with chimpanzees.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Folding of the primate brain cortex allows for improved neural processing power by increasing cortical surface area for the allocation of neurons. The arrangement of folds (sulci) and ridges (gyri) across the cerebral cortex is thought to reflect the underlying neural network. Gyrification, an adaptive trait with a unique evolutionary history, is affected by genetic factors different from those affecting brain volume. Using a large pedigreed population of ∼1000 Papio baboons, we address critical questions about the genetic architecture of primate brain folding, the interplay between genetics, brain anatomy, development, patterns of cortical-cortical connectivity, and gyrification's potential for future evolution. Through Mantel testing and cluster analyses, we find that the baboon cortex is quite evolvable, with high integration between the genotype and phenotype. We further find significantly similar partitioning of variation between cortical development, anatomy, and connectivity, supporting the predictions of tension-based models for sulcal development. We identify a significant, moderate degree of genetic control over variation in sulcal length, with gyrus-shape features being more susceptible to environmental effects. Finally, through QTL mapping, we identify novel chromosomal regions affecting variation in brain folding. The most significant QTL contain compelling candidate genes, including gene clusters associated with Williams and Down syndromes. The QTL distribution suggests a complex genetic architecture for gyrification with both polygeny and pleiotropy. Our results provide a solid preliminary characterization of the genetic basis of primate brain folding, a unique and biomedically relevant phenotype with significant implications in primate brain evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.