ArticleGenetics2015
Ancestral Relationships Using Metafounders: Finite Ancestral Populations and Across Population Relationships.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Evaluation of Multi-Breed Genomic Prediction Models for Carcass and Reproductive Traits in Zebu Beef Cattle.Animal genetics · 2026Article
- Implementation of Metafounders in the Genomic Prediction for the Polled Trait in Brahman Cattle Using a Multi-Breed Population.Animal genetics · 2026Article
- Better Multi-Breed Genomic Predictions for Tropical Bull Fertility Using a Breed-Adjusted Genomic Relationship Matrix.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- From linear models to deep learning: statistical advances in genomic selection for animal breeding.Journal of animal science and biotechnology · 2026Review
- Genomic selection validated across two generations of loblolly pine breeding.G3 (Bethesda, Md.) · 2026Article
- Use of Cluster Analysis for Identifying Metafounders.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Computing inbreeding coefficients accounting for unknown parents using pedigree-based metafounders.JDS communications · 2026Article
- Computational and modeling approaches for US threshold genetic evaluations of calving ease.JDS communications · 2026Article
- A modified indirect method for computing inbreeding coefficients.Genetics, selection, evolution : GSE · 2026Article
- A genome-wide assessment of the population structure of thirteen admixed and pure Australian beef cattle breeds.Journal of animal science · 2026Article
- On ARGs, pedigrees, and genetic relatedness matrices.Genetics · 2026Article
- Indirect Genomic Predictions for Indicine Cattle Breeds With SNP Effects From a Multi-Breed Genomic Evaluation.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Genomic Evaluation in Nellore Cattle for Reproductive Traits: Multiple Ways to Account for Missing Pedigrees.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Multi-Breed Genomic Predictions for Average Daily Gain in Three Italian Beef Cattle Breeds.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Comparison between repeatability, reproductive stage stratified repeatability, and relative risk models for prediction of breeding values for functional survival in rotationally crossbred sows.Genetics, selection, evolution : GSE · 2025Article
- Estimation of (co)variance components for very large datasets and complex single-step genomic models.Genetics, selection, evolution : GSE · 2025Article
- randPedPCA: rapid approximation of principal components from large pedigrees.Genetics, selection, evolution : GSE · 2025Article
- Shared SNP effects across breeds increase the genomic prediction accuracy for numerically small breeds.Scientific reports · 2025Article
- Article
- Modern pedigree dogs in the United Kingdom Kennel Club: a journey through shifting population landscapes and demography.Companion animal health and genetics · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships. We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view which each population is considered as an infinite, unrelated pool. Several ancestral populations may be connected and therefore related. Each ancestral population can be represented as a "metafounder," a pseudo-individual included as founder of the pedigree and similar to an "unknown parent group." Metafounders have self- and across relationships according to a set of parameters, which measure ancestral relationships, i.e., homozygozities within populations and relationships across populations. These parameters can be estimated from existing pedigree and marker genotypes using maximum likelihood or a method based on summary statistics, for arbitrarily complex pedigrees. Equivalences of genetic variance and variance components between the classical and this new parameterization are shown. Segregation variance on crosses of populations is modeled. Efficient algorithms for computation of relationship matrices, their inverses, and inbreeding coefficients are presented. Use of metafounders leads to compatibility of genomic and pedigree relationship matrices and to simple computing algorithms. Examples and code are given.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.