ArticleScientific reports2015
Intronic deletions of tva receptor gene decrease the susceptibility to infection by avian sarcoma and leukosis virus subgroup A.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Genetic mutations within tva receptor gene confer resistance to ALV-A and ALV-K infection in chickens.Poultry science · 2026Article
- Generation of chimeric chickens resistant to infection by avian leukemia virus subgroups A, B, D, E, and K through primordial germ cells.Poultry science · 2026Article
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Single Amino Acid Residue W33 ofViruses · 2025Article
- Meta-analysis of heritability estimates and genome-wide association for tick-borne haemoparasites in African cattle.Frontiers in genetics · 2023Article
- Advances on genetic and genomic studies of ALV resistance.Journal of animal science and biotechnology · 2022Review
- A locus conferring tolerance to Theileria infection in African cattle.PLoS genetics · 2022Article
- Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication.Frontiers in immunology · 2022Review
- Knock-Out of Retrovirus Receptor GeneViruses · 2021Article
- Endogenous Avian Leukosis Virus in Combination with Serotype 2 Marek's Disease Virus Significantly Boosted the Incidence of Lymphoid Leukosis-Like Bursal Lymphomas in Susceptible Chickens.Journal of virology · 2019Article
- Co-infection of vvMDV with multiple subgroups of avian leukosis viruses in indigenous chicken flocks in China.BMC veterinary research · 2019Article
- Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J.Journal of animal science and biotechnology · 2019Article
- Naturally Occurring Frameshift Mutations in theJournal of virology · 2018Article
- A premature stop codon within theOncotarget · 2017Article
- Acquisition of resistance to avian leukosis virus subgroup B through mutations on tvb cysteine-rich domains in DF-1 chicken fibroblasts.Veterinary research · 2017Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The group of avian sarcoma and leukosis virus (ASLV) in chickens contains six highly related subgroups, A to E and J. Four genetic loci, tva, tvb, tvc and tvj, encode for corresponding receptors that determine the susceptibility to the ASLV subgroups. The prevalence of ASLV in hosts may have imposed strong selection pressure toward resistance to ASLV infection, and the resistant alleles in all four receptor genes have been identified. In this study, two new alleles of the tva receptor gene, tva(r5) and tva(r6), with similar intronic deletions were identified in Chinese commercial broilers. These natural mutations delete the deduced branch point signal within the first intron, disrupting mRNA splicing of the tva receptor gene and leading to the retention of intron 1 and introduction of premature TGA stop codons in both the longer and shorter tva isoforms. As a result, decreased susceptibility to subgroup A ASLV in vitro and in vivo was observed in the subsequent analysis. In addition, we identified two groups of heterozygous allele pairs which exhibited quantitative differences in host susceptibility to ASLV-A. This study demonstrated that defective splicing of the tva receptor gene can confer genetic resistance to ASLV subgroup A in the host.
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