ArticleEpilepsy & behavior : E&B2015
Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy.
Article in Epilepsy & behavior : E&B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Interhemispheric Functional Hypoconnectivity Is an Early Marker of Cortical Epileptogenesis.Biomedicines · 2026Article
- Disparities in Connectivity Profiles Between Structural and Functional Networks in Patients With Temporal Lobe Epilepsy.Brain and behavior · 2025Article
- Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy.Journal of neurosurgery · 2025Article
- Social brain networks: Resting-state and task-based connectivity in youth with and without epilepsy.Neuropsychologia · 2021Article
- Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy.Scientific reports · 2021Article
- Functional network topology in drug resistant and well-controlled idiopathic generalized epilepsy: a resting state functional MRI study.Brain communications · 2021Article
- MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture.Network neuroscience (Cambridge, Mass.) · 2021Article
- Comparison of topological properties of functional brain networks with graph theory in temporal lobe epilepsy with different duration of disease.Annals of translational medicine · 2020Article
- The morphological characteristics of hippocampus and thalamus in mesial temporal lobe epilepsy.BMC neurology · 2020Article
- A Magnetoencephalography Study of Pediatric Interictal Neuromagnetic Activity Changes and Brain Network Alterations Caused by Epilepsy in the High Frequency (80-1000 Hz).IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
- Epilepsy as a dynamic disease: A Bayesian model for differentiating seizure risk from natural variability.Epilepsia open · 2018Article
- A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model.Frontiers in cellular neuroscience · 2018Article
- Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings.Epilepsia · 2016Review
- Large-scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy.Human brain mapping · 2016Article
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5 authors.
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Abstract
Temporal lobe epilepsy (TLE) is often associated with progressive changes to seizures, memory, and mood during its clinical course. However, the cerebral changes related to this progression are not well understood. Because the changes may be related to changes in brain networks, we used functional connectivity MRI (fcMRI) to determine whether brain network parameters relate to the duration of TLE. Graph theory-based analysis of the sites of reported regions of TLE abnormality was performed on resting-state fMRI data in 48 subjects: 24 controls, 13 patients with left TLE, and 11 patients with right TLE. Various network parameters were analyzed including betweenness centrality (BC), clustering coefficient (CC), path length (PL), small-world index (SWI), global efficiency (GE), connectivity strength (CS), and connectivity diversity (CD). These were compared for patients with TLE as a group, compared to controls, and for patients with left and right TLE separately. The association of changes in network parameters with epilepsy duration was also evaluated. We found that CC, CS, and CD decreased in subjects with TLE compared to control subjects. Analyzed according to epilepsy duration, patients with TLE showed a progressive reduction in CD. In conclusion, we found that several network parameters decreased in patients with TLE compared to controls, which suggested reduced connectivity in TLE. Reduction in CD associated with epilepsy duration suggests a homogenization of connections over time in TLE, indicating a reduction of the normal repertoire of stronger and weaker connections to other brain regions.
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