ArticleEvolution; international journal of organic evolution2015
Centromere-associated meiotic drive and female fitness variation in Mimulus.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Review
- Natural variation modifies centromere-proximal meiotic crossover frequency and segregation distortion in Arabidopsis thaliana.Genetics · 2026Article
- Reciprocal constraint couples architectural protein abundance and pericentromeric satellite expansion.bioRxiv : the preprint server for biology · 2026Article
- Recombination shapes the diversification of theeLife · 2026Article
- Contemporary hybridization among Arabis floodplain species creates opportunities for adaptation.The New phytologist · 2026Article
- Centromeres drive and take a break.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- Article
- A selfish supergene causes meiotic drive through both sexes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptive evolution of CENP-T modulates centromere binding.Current biology : CB · 2025Article
- Centromere drive may propel the evolution of chromosome and genome size in plants.Annals of botany · 2024Article
- Testing the evolutionary theory of inversion polymorphisms in the yellow monkeyflower (Mimulus guttatus).Nature communications · 2024Article
- Modeling the evolution of Schizosaccharomyces pombe populations with multiple killer meiotic drivers.G3 (Bethesda, Md.) · 2024Article
- Selfing Promotes Spread and Introgression of Segregation Distorters in Hermaphroditic Plants.Molecular biology and evolution · 2024Article
- Proliferation and dissemination of killer meiotic drive loci.Current opinion in genetics & development · 2023Review
- The genomic scale of fluctuating selection in a natural plant population.Evolution letters · 2022Article
- Article
- Centromere drive: model systems and experimental progress.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2022Review
- Supergene potential of a selfish centromere.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Evolution of eukaryotic centromeres by drive and suppression of selfish genetic elements.Seminars in cell & developmental biology · 2022Review
- Complete genomic and epigenetic maps of human centromeres.Science (New York, N.Y.) · 2022Article
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2 authors.
Funding
Abstract
Female meiotic drive, in which chromosomal variants preferentially segregate to the egg pole during asymmetric female meiosis, is a theoretically pervasive but still mysterious form of selfish evolution. Like other selfish genetic elements, driving chromosomes may be maintained as balanced polymorphisms by pleiotropic or linked fitness costs. A centromere-associated driver (D) with a ∼58:42 female-specific transmission advantage occurs at intermediate frequency (32-40%) in the Iron Mountain population of the yellow monkeyflower, Mimulus guttatus. Previously determined male fertility costs are sufficient to prevent the fixation of D, but predict a higher equilibrium frequency. To better understand the dynamics and effects of D, we developed a new population genetic model and measured genotype-specific lifetime female fitness in the wild. In three of four years, and across all years, D imposed significant recessive seedset costs, most likely due to hitchhiking by deleterious mutations. With both male and female costs as measured, and 58:42 drive, our model predicts an equilibrium frequency of D (38%) very close to the observed value. Thus, D represents a rare selfish genetic element whose local population genetic dynamics have been fully parameterized, and the observation of equilibrium sets the stage for investigations of coevolution with suppressors.
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