ArticleCancer prevention research (Philadelphia, Pa.)2015
Anti-Müllerian hormone concentrations in premenopausal women and breast cancer risk.
Article in Cancer prevention research (Philadelphia, Pa.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.Human reproduction (Oxford, England) · 2022Pooled it
- Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Trial
- Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females.Nutrients · 2025Article
- Anti-Müllerian hormone: biology and role in endocrinology and cancers.Frontiers in endocrinology · 2024Review
- The roles of anti-Müllerian hormone in breast cancer.Endocrine-related cancer · 2023Review
- Anti-Müllerian hormone levels and breast cancer risk in the study of women's health across the nation.Cancer causes & control : CCC · 2022Article
- Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women.The Journal of clinical endocrinology and metabolism · 2021Article
- Outdoor air pollution and anti-Müllerian hormone concentrations in the Sister Study.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Abnormal anti-Müllerian hormone level may be a trigger for breast cancer in young women: A case-control study.International journal of reproductive biomedicine · 2021Article
- Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women.medRxiv : the preprint server for health sciences · 2020Article
- Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan.Human molecular genetics · 2019Article
- Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model.Breast cancer research : BCR · 2019Article
- Dietary factors and serum antimüllerian hormone concentrations in late premenopausal women.Fertility and sterility · 2018Article
- Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts.International journal of cancer · 2018Article
- Circulating Hormones and Mammographic Density in Premenopausal Women.Hormones & cancer · 2018Article
- Anti-Mullerian hormone and endometrial cancer: a multi-cohort study.British journal of cancer · 2017Article
- Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine.Journal of assisted reproduction and genetics · 2017Review
- Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women.Fertility and sterility · 2017Article
- Serum anti-mullerian hormone and all-cause mortality in men.Endocrine · 2016Article
- Antimüllerian hormone in relation to tobacco and marijuana use and sources of indoor heating/cooking.Fertility and sterility · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Laboratory models support an inverse association between anti-Müllerian hormone (AMH) and breast tumor development. Human studies are lacking; one study (N = 105 cases, 204 controls) with prospectively collected serum reported the opposite-an approximate 10-fold increase in breast cancer risk comparing fourth with first quartile AMH levels. We investigated the relation between serum AMH levels and breast cancer risk in a case-control (N = 452 cases, 902 controls) study nested within the prospective Sister Study cohort of 50,884 women. At enrollment, participants were ages 35 to 54, premenopausal, and completed questionnaires on medical and family history, lifestyle factors, and demographics. AMH (ng/mL) was measured by ultrasensitive ELISA in serum collected at enrollment and log-transformed for analysis. Multivariate conditional logistic regression was used to calculate ORs and 95% confidence intervals (CI) to account for matching on age and enrollment year. Mean age at enrollment was 46.8 years with an average 2.9 years from blood draw to breast cancer diagnosis (SD = 1.9). AMH concentrations were below the limit of detection (0.003 ng/mL) for approximately 25% of samples. Compared with samples below the LOD, women with AMH >2.84 ng/mL (90th percentile among controls) had a 2-fold increase in breast cancer odds (OR, 2.25; 95% CI, 1.26-4.02). For each 1-unit increase in lnAMH, overall breast cancer odds increased by 8% (OR, 1.08; 95% CI, 1.02-1.15) and odds of estrogen receptor-positive, invasive disease increased by 15% (OR, 1.15; 95% CI, 1.05-1.25). Our findings demonstrate an overall positive relation between AMH and breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.