Evidence map›Paper›PMID 25873348›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2015

Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes.

Yating Cheng, Un-Ho Jin, Clint D Allred, Arul Jayaraman, Robert S Chapkin, Stephen Safe

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 126 citations in OpenAlex.

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  2. Assessment of the relationship between AHR, sdLDL, Klotho biomarkers, and etiologic subtypes in young to middle-aged acute ischemic stroke according to toast classification.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yating ChengDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas.
Un-Ho JinDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas.
Clint D AllredDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas.
Arul JayaramanDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas.
Robert S ChapkinDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas.
Stephen SafeDepartment of Veterinary Physiology and Pharmacology (Y.C., U.-H.J., S.S.), Department of Nutrition and Food Science (C.D.A., R.S.C.), Department of Chemical Engineering (A.J.), Texas A&M University, College Station, Texas ssafe@cvm.tamu.edu.
Texas A&M University · US

Funding

TARGETED GENOMICS FACILITY COREP30ES023512 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI DEUTZ, NICOLAAS E · 2014 to 2017
$3.3M
NIEHS NIH HHS P30 ES023512NIEHS NIH HHS P30-ES023512
6 · The paper itself

Abstract

The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells. Using Cyp1a1 mRNA as an Ah-responsive end point, we observed that the tryptophan metabolites were weak AhR agonists and partial antagonists in YAMC cells, and the pattern of activity was different from that previously observed in CaCo2 colon cancer cells. However, expansion of the end points to other Ah-responsive genes including the Cyp1b1, the AhR repressor (Ahrr), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiParp) revealed a highly complex pattern of AhR agonist/antagonist activities that were both ligand- and gene-dependent. For example, the magnitude of induction of Cyp1b1 mRNA was similar for TCDD, tryptamine, and indole-3-acetate, whereas lower induction was observed for indole and indole-3-aldehyde was inactive. These results suggest that the tryptophan metabolites identified in microbiota are selective AhR modulators.

Indexed as

Age FactorsAnimalsCaco-2 CellsColonDose-Response Relationship, DrugHumansMicePolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonTryptophanPolychlorinated DibenzodioxinsReceptors, Aryl HydrocarbonTryptophan

Identifiers

PMID25873348
PMCPMC4576676
OpenAlexW2145635845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.