ArticleCancer2015
Practical communication guidance to improve phase 1 informed consent conversations and decision-making in pediatric oncology.
Article in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Moving toward precision communication in pediatric oncology clinical trials: An outline of a conceptual framework to support caregiver decision-making.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Differences in Patient and Parent Preferences for Prognostic Communication Across Disease Milestones in Advanced Childhood Cancer.Pediatric blood & cancer · 2025Article
- The state of targeted therapeutic pharmacological approaches in pediatric neurosurgery: report from the European Society for Pediatric Neurosurgery (ESPN) Consensus Conference 2024.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Gene therapy in sickle cell disease: Attitudes and informational needs of patients and caregivers.Pediatric blood & cancer · 2023Article
- Approaches for Discussing Clinical Trials with Pediatric Oncology Patients and Their Families.Current oncology reports · 2022Review
- Parents' Insights into Pediatric Oncology Phase I Clinical Trials: Experiences from Their Child's Participation.Seminars in oncology nursing · 2021Review
- Communication of Pharmacogenomic test results and treatment plans in pediatric oncology: deliberative stakeholder consultations with parents.BMC palliative care · 2021Article
- Ethical Challenges in Pediatric Oncology Care and Clinical Trials.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2021Article
- Persistently low peace of mind in parents of cancer patients: A five-year follow-up study.Pediatric blood & cancer · 2019Article
- Inclusion of children in the initial conversation about their cancer diagnosis: impact on parent experiences of the communication process.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Communication in pediatric oncology: State of the field and research agenda.Pediatric blood & cancer · 2018Review
- Communication Skills Training in Pediatric Oncology: Moving Beyond Role Modeling.Pediatric blood & cancer · 2016Review
- Understanding parental refusal of permission for child participation in surgical prospective trials.Pediatric surgery international · 2016Observational
- Ethical Challenges of Pediatric Cancer Care: Interviews With Nurses in Saudi Arabia.Cancer control : journal of the Moffitt Cancer CenterArticle
- Assent Described: Exploring Perspectives From the Inside.Journal of pediatric nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundIt can be difficult to explain pediatric phase 1 oncology trials to families of children with refractory cancer. Parents may misunderstand the information presented to them, and physicians may assume that certain topics are covered in the informed consent document and need not be discussed. Communication models can help to ensure effective discussions.
methodsSuggestions for improving the informed consent process were first solicited from phase 1 study clinicians via questionnaire. Eight parents who had enrolled their child on a phase 1 pediatric oncology trial were recruited for an advisory group designed to assess the clinicians' suggestions and make additional recommendations for improving informed consent for pediatric phase 1 trials.
resultsA phase 1 communication model was designed to incorporate the suggestions of clinicians and families. It focused on educating parents/families about phase 1 trials at specific time points during a child's illness, but specifically at the point of disease recurrence. An informative phase 1 fact sheet that can be distributed to families was also presented.
conclusionsFamilies who will be offered information regarding phase 1 clinical trials can first receive a standardized fact sheet explaining the general purpose of these early-phase clinical trials. Parental understanding may be enhanced further when oncologists address key themes, beginning at the time of diagnosis and continuing through important decision points during the child's illness. This model should be prospectively evaluated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.