ArticleAngewandte Chemie (International ed. in English)2015
Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
- Tumor radiosensitization with gold nanoparticles: evolving strategies to improve tumoral gold uptake and catalyze future clinical translation.ACS nano medicine · 2026Article
- Review
- Celastrol Derivative/DOX Co-Assembled Nanodrug for Enhanced Antitumor Therapy.Current drug delivery · 2026Article
- Polyglycerol-Grafted Graphene Oxide with pH-Responsive Charge-Convertible Surface to Dynamically Control the Nanobiointeractions for Enhanced in Vivo Tumor Internalization.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Gold Nanoparticle-based Biosensors for Point-of-Care Diagnostics: A Review of Sensing Nanoparticle Applications and Future Prospects.Combinatorial chemistry & high throughput screening · 2025Review
- Stealth and Biocompatible Gold Nanoparticles through Surface Coating with a Zwitterionic Derivative of Glutathione.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers.Asian journal of pharmaceutical sciences · 2024Review
- Article
- Biological Interaction and Imaging of Ultrasmall Gold Nanoparticles.Nano-micro letters · 2023Review
- Physicochemical Properties and Route of Systemic Delivery Control the In Vivo Dynamics and Breakdown of Radiolabeled Gold Nanostars.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- How Does the Study MD of pH-Dependent Exposure of Nanoparticles Affect Cellular Uptake of Anticancer Drugs?International journal of molecular sciences · 2023Article
- A comprehensive approach to developing a multi-epitope vaccine againstFrontiers in immunology · 2023Article
- pH-triggered cancer-targeting polymers: From extracellular accumulation to intracellular release.Nano research · 2023Review
- Polyethyleneimine-Based Drug Delivery Systems for Cancer Theranostics.Journal of functional biomaterials · 2022Review
- Review
- Hollow carbon nanospheres embedded with stoichiometric γ-FeNanoscale advances · 2022Article
- Effects of the Surface Charge of Graphene Oxide Derivatives on Ocular Compatibility.Nanomaterials (Basel, Switzerland) · 2022Article
- Gold-Polymer Nanocomposites for Future Therapeutic and Tissue Engineering Applications.Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.