Evidence map›Paper›PMID 25873178›Full record

ArticleInternational journal of epidemiology2015

Behavioural effects of fetal antidepressant exposure in a Norwegian cohort of discordant siblings.

Ragnhild Eek Brandlistuen, Eivind Ystrom, Malin Eberhard-Gran, Irena Nulman, Gideon Koren, Hedvig Nordeng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 75 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ragnhild Eek BrandlistuenPharmacoepidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, Oslo, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway, r.e.brandlistuen@farmasi.uio.no.
Eivind YstromDivision of Mental Health, Norwegian Institute of Public Health, Oslo, Norway, Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway and.
Malin Eberhard-GranDivision of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Irena NulmanMotherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada.
Gideon KorenMotherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada.
Hedvig NordengPharmacoepidemiology and Drug Safety Research Group, School of Pharmacy, University of Oslo, Oslo, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Norwegian Institute of Public Health · NOUniversity of Oslo · NOHospital for Sick Children · CAUniversity of Toronto · CA

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
NINDS NIH HHS 1 UO1 NS 047537-01NINDS NIH HHS 2 UO1 NS 047537-06A1
6 · The paper itself

Abstract

objectivePotential adverse effects of prenatal antidepressant exposure on child development are still debated. The possibility that associations are due to genetic or familial environmental risk factors rather than antidepressant use per se cannot easily be ruled out in conventional studies. Our objective was therefore to evaluate the association between prenatal antidepressant exposure and behavioural problems in a sibling controlled study.

methodThis study used data on 20 180 siblings identified from the population-based Norwegian Mother and Child Cohort Study recruited between 1999 and 2008. The mothers were asked to report antidepressant use at gestational weeks 17 and 30 and 6 months post-partum. Child Behavioral Checklist syndrome scales were used to assess externalizing and internalizing behavioural problems by questionnaires sent to mothers at 18 and 36 months postpartum. We performed unmatched and matched sibling analyses using both random- and fixed-effects linear models, respectively, to determine potential behavioural effects of antidepressant exposure.

resultsPrenatal exposure to antidepressants was associated with increased levels of anxiety symptoms in 3 year old children after adjusting for maternal familial effects and confounding by indication (i.e. maternal depression). Effect of prenatal exposure to antidepressants was specific to anxiety, and not associated with emotional reactivity, somatic complaints, sleep problems, attention problems or aggression.

conclusionUsing a sibling design, we showed that prenatal antidepressant use was specifically associated with increased anxiety symptoms after adjusting for maternal familial factors and confounding by indication.

Indexed as

AdultAntidepressive AgentsChild Behavior DisordersChild DevelopmentChild, PreschoolCohort StudiesDepressionFemaleHumansInfantMaleMaternal ExposureMothersNorwayPregnancyPregnancy ComplicationsAntidepressive AgentsAntidepressantschild behaviourdepressionNorwegian Mother and Child Cohort Study (MoBa)pregnancysibling design

Identifiers

PMID25873178
PMCPMC4588862
OpenAlexW2111547956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.