When one mutation is all it takes.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed.

1. Risk of leukemia in twins.Haematologica · 2025
   Article
2. Convergent TP53 loss and evolvability in cancer.BMC ecology and evolution · 2023
   Review
3. Non-genetic determinants of malignant clonal fitness at single-cell resolution.Nature · 2022
   Article
4. A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia.ChemMedChem · 2021
   Review
5. Non-genetic mechanisms of therapeutic resistance in cancer.Nature reviews. Cancer · 2020
   Review
6. Exploitable metabolic dependencies in MLL-ENL-induced leukemia.Blood advances · 2020
   Article
7. The Impact of PI3-kinase/RAS Pathway Cooperating Mutations in the Evolution ofHemaSphere · 2019
   Review
8. Simultaneous involvement of 11q23 translocation resulting in chimeric MLL-AFF1 and a second translocation [t (9;21) (p13; p11.2)] in an infant acute lymphoblastic leukemia patient at relapse: A case report.Medicine · 2018
   Article
9. The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.Biochimica et biophysica acta. Molecular cell research · 2018
   Article
10. Mutations, Cancer and the Telomere Length Paradox.Trends in cancer · 2017
    Review
11. Childhood hematologic cancer and residential proximity to oil and gas development.PloS one · 2017
    Article
12. Environmental, maternal, and reproductive risk factors for childhood acute lymphoblastic leukemia in Egypt: a case-control study.BMC cancer · 2016
    Article
13. Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.PLoS genetics · 2016
    Article
14. The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism.Oncotarget · 2016
    Article
15. Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.Annals of laboratory medicine · 2016
    Review
16. Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
17. Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia.Blood · 2015
    Review
18. Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor.Frontiers in oncology · 2015
    Article

Corrections and comments

• Comment on
  The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.2015

Authors and funding

1 author.

Funding

Abstract

Indexed as