Evidence map›Paper›PMID 25873142›Full record

Trial reportTrials2015

Advancing Survivors' Knowledge (ASK) about skin cancer study: study protocol for a randomized controlled trial.

Casey L Daniel, Gregory T Armstrong, Robyn R Keske, Jessica A Davine, Aaron J McDonald, Kim M Sprunck-Harrild, Catherine Coleman, Sebastien J Haneuse, Ann C Mertens, Karen M Emmons and 5 more

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02046811 (Reducing Skin Cancer Risk in Childhood Cancer Survivors), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02046811 nacompletednot on this map

Reducing Skin Cancer Risk in Childhood Cancer Survivors

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2015 to 2018Enrolled726ConditionsSkin NeoplasmsArmsPatient activation and education (PAE), PAE plus physician activation (PAE + MD), PAE physician activation, plus teledermoscopy (PAE +MD +TD)
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Health Care Transitions Among Adolescents and Young Adults With Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2020
    Article
  8. Review
  9. Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Review
  10. Recent trends in teledermatology and teledermoscopy.Dermatology practical & conceptual · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Casey L DanielDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Kresge 718, 02115-6028, Boston, MA, USA. casey_daniel@dfci.harvard.edu.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 735, 38105-3678, Memphis, TN, USA. greg.armstrong@stjude.org.
Robyn R KeskeDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Kresge 718, 02115-6028, Boston, MA, USA. rkeske@hsph.harvard.edu.
Jessica A DavineDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Kresge 718, 02115-6028, Boston, MA, USA. jdavine@hsph.harvard.edu.
Aaron J McDonaldDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 735, 38105-3678, Memphis, TN, USA. aaron.mcdonald@stjude.org.
Kim M Sprunck-HarrildDepartment of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, LW601, 02215-5450, Boston, MA, USA. kim_sprunckharrild@dfci.harvard.edu.
Catherine ColemanDepartment of Population Sciences, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02215-5450, Boston, MA, USA. catherine_coleman@dfci.harvard.edu.
Sebastien J HaneuseDepartment of Biostatistics, Harvard TH Chan School of Public Health, 655 Huntington Avenue, Bldg 2, Rm 451, 02115-6009, Boston, MA, USA. shaneuse@hsph.harvard.edu.
Ann C MertensDepartment of Pediatrics, Emory University, Emory Children's Center, 2015 Uppergate Drive, 4th floor, 30322-1014, Atlanta, GA, USA. ann.mertens@choa.org.
Karen M EmmonsKaiser Permanente, 1800 Harrison Street, 16th Floor, #161R03, 94612-3463, Oakland, CA, USA. karen.m.emmons@kp.org.
Ashfaq A MarghoobMemorial-Sloan Kettering Cancer Center, 1275 York Ave, 10065-6007, New York, NY, USA. marghooa@mskcc.org.
Elena B ElkinDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 44, 10065-6007, New York, NY, USA. elkine@mskcc.org.
Stephen W DuszaDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, 160 East 53rd St, 2nd Floor, 10022-5243, New York, NY, USA. duszas@mskcc.org.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 735, 38105-3678, Memphis, TN, USA. les.robison@stjude.org.
Alan C GellerDepartment of Social and Behavioral Sciences, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Kresge 718, 02115-6028, Boston, MA, USA. ageller@hsph.harvard.edu.
Memorial Sloan Kettering Cancer Center · USSt. Jude Children's Research Hospital · USHarvard University · USDana-Farber Cancer Institute · USEmory University · USKaiser Permanente Oakland Medical Center · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Harvard Education Program in Cancer Prevention Control (R25T)R25CA057711 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI DAVISON, KIRSTEN · 1992 to 2018
$8.5M
Reducing Skin Cancer Risk in Childhood Cancer SurvivorsR01CA175231 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI GELLER, ALAN CHARLES · 2013 to 2017
$3.4M
The Harvard Chan Education Program in Cancer Prevention and ControlT32CA057711 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Karen M. Emmons, ANNE LINDSAY FRAZIER · 2019 to 2026
$3.3M
CHILDHOOD CANCER SURVIVOR STUDYU01CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROBISON, LESLIE L · 1993 to 1999
–
NCI NIH HHS 5P30 CA06516NCI NIH HHS CA55727NCI NIH HHS P30 CA006516NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA175231NCI NIH HHS R25 CA057711NCI NIH HHS T32 CA057711NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

backgroundAdvances in treatment have increased childhood cancer 5-year survival rates to greater than 80%. However, children previously treated with radiation are at significantly increased risk of developing subsequent neoplasms, the most common of which are skin cancers. The National Cancer Institute and Children's Oncology Group have issued recommendations for survivors treated with radiation to perform monthly skin self-examinations and receive a physician skin examination at least annually, as early detection has demonstrated markedly improved outcomes in the diagnosis and treatment of skin cancers. The goal of the present study is to increase rates of skin self-examinations and clinical skin examinations among adult survivors of childhood cancer treated with radiation. METHODS/

designThis randomized controlled trial uses a 3-group comparative effectiveness design comparing: (1) Patient Activation and Education (PAE) including text messaging, print and web-based tutorials over 12 months; (2) PAE plus physician activation (PAE + MD) adding physician activation/educational materials about survivors' increased skin cancer risk and conducting full-body skin exams; and (3) PAE plus physician activation, plus teledermoscopy (PAE + MD + TD) adding participant receipt of a dermatoscope intended to empower them to photograph suspect moles or lesions for review by the study dermatologist. DISCUSSION: The current study addresses barriers to screening in this population by providing educational and motivational information for both survivors and physicians regarding the value of periodic skin examinations. It also utilizes innovative mobile health technology to encourage and motivate (that is activate) survivors to conduct skin self-examinations, request physician exams, and obtain treatment when worrisome lesions are found. Finally, as a comparative effectiveness trial, this study isolates the effects of adding specific components to the patient activation intervention to test the most effective intervention for enhancing skin examination vigilance among this high-risk group.

trial registrationClinicaltrials.gov: NCT02046811 ; Registration date: 22 January 2014.

Indexed as

Health Knowledge, Attitudes, PracticeCanadaComparative Effectiveness ResearchDermoscopyEarly Detection of CancerHealth BehaviorHumansInternetMotivationNeoplasmsNeoplasms, Radiation-InducedPamphletsPatient Education as TopicPredictive Value of TestsResearch DesignRisk Factors

Identifiers

PMID25873142
PMCPMC4392639
OpenAlexW2076431949

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.