Evidence map›Paper›PMID 25873038›Full record

ReviewNature reviews. Neuroscience2015

Decision making in the ageing brain: changes in affective and motivational circuits.

Gregory R Samanez-Larkin, Brian Knutson

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. Contributions of the basolateral amygdala and nucleus accumbens to sustaining not just initiating cognitive effort.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. The Social Iowa Gambling Task: a promising tool for assessing deception detection in real-world contexts in adulthood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  14. Article
  15. Alzheimer's Disease Pathologies Affect Dopaminergic Neural Mechanisms of Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  16. Article
  17. Article
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  19. Review
  20. Review

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gregory R Samanez-Larkin1] Department of Psychology, 2 Hillhouse Avenue, Yale University, New Haven, Connecticut 06520, USA. [2].
Brian Knutson1] Department of Psychology, Building 420, Jordan Hall, Stanford University, Stanford, California 94305, USA. [2].

Funding

Neuromodulation of Motivated Cognition and Decision Making Across AdulthoodR00AG042596 · NIA · YALE UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2014 to 2016
$730k
Anticipation of Reward and Risk Across the LifespanR21AG030778 · NIA · STANFORD UNIVERSITY · PI KNUTSON, BRIAN · 2007 to 2008
$493k
Incentive learning and decision making in the aging brainF31AG032804 · NIA · STANFORD UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2008 to 2010
$77k
Imaging the Human Reward System Across the Adult Life SpanF32AG039131 · NIA · VANDERBILT UNIVERSITY · PI SAMANEZ LARKIN, GREGORY R · 2011 to 2012
$53k
NIA NIH HHS F31 AG032804NIA NIH HHS F31AG032804NIA NIH HHS F32 AG039131NIA NIH HHS F32AG039131NIA NIH HHS R00 AG042596NIA NIH HHS R00AG042596NIA NIH HHS R21 AG030778NIA NIH HHS R21AG030778
6 · The paper itself

Abstract

As the global population ages, older decision makers will be required to take greater responsibility for their own physical, psychological and financial well-being. With this in mind, researchers have begun to examine the effects of ageing on decision making and associated neural circuits. A new 'affect-integration-motivation' (AIM) framework may help to clarify how affective and motivational circuits support decision making. Recent research has shed light on whether and how ageing influences these circuits, providing an interdisciplinary account of how ageing can alter decision making.

Indexed as

AgedAged, 80 and overAgingBrainDecision MakingHumansMotivationNerve Net

Identifiers

PMID25873038
PMCPMC5645075

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.