ArticleHuman brain mapping2015
Integrity of white matter microstructure in alcoholics with and without Korsakoff's syndrome.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Social cognition in Korsakoff's syndrome: A meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder.Translational psychiatry · 2022Pooled it
- Compensation patterns and altered functional connectivity in alcohol use disorder with and without Korsakoff's syndrome.Brain communications · 2024Article
- A Clinician's View of Wernicke-Korsakoff Syndrome.Journal of clinical medicine · 2022Review
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- Role of inflammation in alcohol-related brain abnormalities: a translational study.Brain communications · 2021Article
- When affect overlaps with concept: emotion recognition in semantic variant of primary progressive aphasia.Brain : a journal of neurology · 2020Article
- Accelerated aging and motor control deficits are related to regional deformation of central cerebellar white matter in alcohol use disorder.Addiction biology · 2020Article
- A Pivotal Role for Thiamine Deficiency in the Expression of Neuroinflammation Markers in Models of Alcohol-Related Brain Damage.Alcoholism, clinical and experimental research · 2019Article
- A patient with Korsakoff syndrome of psychiatric and alcoholic etiology presenting as DSM-5 mild neurocognitive disorder.Neuropsychiatric disease and treatment · 2019Article
- The Regulatory Role of the Human Mediodorsal Thalamus.Trends in cognitive sciences · 2018Review
- Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy.Molecular neurobiology · 2018Article
- Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Article
- Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism.NeuroImage. Clinical · 2018Article
- Korsakoff Syndrome in Non-alcoholic Psychiatric Patients. Variable Cognitive Presentation and Impaired Frontotemporal Connectivity.Frontiers in psychiatry · 2018Article
- Alcoholism and sexual dimorphism in the middle longitudinal fascicle: a pilot study.Brain imaging and behavior · 2017Article
- Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4T.Drug and alcohol dependence · 2017Article
- Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models.Alcohol research : current reviews · 2017Review
- Investigation of Cognitive Improvement in Alcohol-Dependent Inpatients Using the Montreal Cognitive Assessment (MoCA) Score.Journal of addiction · 2016Article
- Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol dependence results in two different clinical forms: "uncomplicated" alcoholism (UA) and Korsakoff's syndrome (KS). Certain brain networks are especially affected in UA and KS: the frontocerebellar circuit (FCC) and the Papez circuit (PC). Our aims were (1) to describe the profile of white matter (WM) microstructure in FCC and PC in the two clinical forms, (2) to identify those UA patients at risk of developing KS using their WM microstructural integrity as a biomarker. Tract-based spatial statistics and nonparametric voxel-based permutation tests were used to compare diffusion tensor imaging (DTI) data in 7 KS, 20 UA, and 14 healthy controls. The two patient groups were also pooled together and compared to controls. k-means classifications were then performed on mean fractional anisotropy values of significant clusters across all subjects for two fiber tracts from the FCC (the middle cerebellar peduncle and superior cerebellar peduncle) and two tracts from the PC (fornix and cingulum). We found graded effects of WM microstructural abnormalities in the PC of UA and KS. UA patients classified at risk of developing KS using fiber tracts of the PC from DTI data also had the lowest scores of episodic memory. That finding suggests that WM microstructure could be used as a biomarker for early detection of UA patients at risk of developing KS.
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