Evidence map›Paper›PMID 25872901›Full record

ArticlePrenatal diagnosis2015

Pregnancy continuation and organizational religious activity following prenatal diagnosis of a lethal fetal defect are associated with improved psychological outcome.

Heidi Cope, Melanie E Garrett, Simon Gregory, Allison Ashley-Koch

Abstract read
In one paragraph

Article in Prenatal diagnosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heidi CopeCenter for Human Disease Modeling, Duke University Medical Center, Durham, NC, USA.
Melanie E GarrettCenter for Human Disease Modeling, Duke University Medical Center, Durham, NC, USA.
Simon Gregory *Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Allison Ashley-Koch *Center for Human Disease Modeling, Duke University Medical Center, Durham, NC, USA.

Funding

The Hereditary Basis of Neural Tube DefectsR01NS039818 · NINDS · DUKE UNIVERSITY · PI ASHLEY-KOCH, ALLISON E · 1999 to 2008
$6.8M
NINDS NIH HHS R01 NS039818
6 · The paper itself

Abstract

objectiveThe aim of the article is to examine the psychological impact, specifically symptoms of grief, post-traumatic stress and depression, in women and men who either terminated or continued a pregnancy following prenatal diagnosis of a lethal fetal defect.

methodThis project investigated a diagnostically homogeneous group composed of 158 women and 109 men who lost a pregnancy to anencephaly, a lethal neural tube defect. Participants completed the Perinatal Grief Scale, Impact of Event Scale - Revised and Beck Depression Inventory-II, which measure symptoms of grief, post-traumatic stress and depression, respectively. Demographics, religiosity and pregnancy choices were also collected. Gender-specific analysis of variance was performed for instrument total scores and subscales.

resultsWomen who terminated reported significantly more despair (p = 0.02), avoidance (p = 0.008) and depression (p = 0.04) than women who continued the pregnancy. Organizational religious activity was associated with a reduction in grief (Perinatal Grief Scale subscales) in both women (p = 0.02, p = 0.04 and p = 0.03) and men (p = 0.047).

conclusionThere appears to be a psychological benefit to women to continue the pregnancy following a lethal fetal diagnosis. Following a lethal fetal diagnosis, the risks and benefits, including psychological effects, of termination and continuation of pregnancy should be discussed in detail with an effort to be as nondirective as possible.

Indexed as

GriefReligionAbortion, EugenicAdaptation, PsychologicalAdolescentAdultAnencephalyDepressionFemaleFetal DeathHumansLogistic ModelsMalePregnancyPrenatal DiagnosisStress Disorders, Post-Traumatic

Identifiers

PMID25872901
PMCPMC4968036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.