ArticleJournal of gynecologic oncology2015
Low initial human papillomavirus viral load may indicate worse prognosis in patients with cervical carcinoma treated with surgery.
Article in Journal of gynecologic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human papillomavirus (HPV) DNA detection in uterine cervix cancer after radiation indicating recurrence: a systematic review and meta-analysis.Journal of gynecologic oncology · 2020Pooled it
- Article
- Article
- β-CATENIN is a positive prognostic marker for HPV-positive head and neck squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- HPV status and HPV16 viral load in anal cancer and its association with clinical outcome.Cancer medicine · 2022Article
- Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma.Molecular oncology · 2022Article
- HPV Status and Individual Characteristics of Human Papillomavirus Infection as Predictors for Clinical Outcome of Locally Advanced Cervical Cancer.Journal of personalized medicine · 2021Article
- Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.British journal of cancer · 2021Article
- Analysis of influencing factors of viral load in patients with high-risk human papillomavirus.Virology journal · 2021Article
- PSMD9 expression correlates with recurrence after radiotherapy in patients with cervical cancer.Oncology letters · 2020Article
- Article
- Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas.Cancers · 2019Article
- Nomograms based on HPV load for predicting survival in cervical squamous cell carcinoma: An observational study with a long-term follow-up.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Human Papillomavirus Status in Primary Lesions and Pelvic Lymph Nodes and Its Prognostic Value in Cervical Cancer Patients with Lymph Node Metastases.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Human papillomavirus genotype prevalence in the women of Shanghai, China and its association with the severity of cervical neoplasia.International journal of clinical and experimental pathology · 2018Article
- Early response to neoadjuvant chemotherapy can help predict long-term survival in patients with cervical cancer.Oncotarget · 2016Article
- The Impact of High-Risk HPV Genotypes Other Than HPV 16/18 on the Natural Course of Abnormal Cervical Cytology: A Korean HPV Cohort Study.Cancer research and treatment · 2016Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the prognostic implication of human papillomavirus (HPV) viral load in cervical cancer patients who underwent radical hysterectomy.
methodsWe conducted a retrospective review of patients with stage IA2 through stage IIIA cervical carcinoma who underwent radical hysterectomy at Sun Yat-sen University Cancer Center between January 2005 and December 2009. Patients who had undergone preoperative hybrid capture 2 testing to detect HPV DNA were included. A total of 346 patients positive for HPV DNA were enrolled and stratified into two groups according to the median HPV viral load.
resultsHPV viral load was significantly correlated with lymphovascular space invasion (p=0.026) and deep stromal invasion (p=0.024). However, other factors, such as age, stage, histologic grade, histologic type, lymph node metastasis, and tumor size, were not significantly associated with viral load. Low HPV viral load was correlated with poor disease-free survival in univariate analysis (p=0.037) and multivariate analysis (p=0.027). There was no significant difference in overall survival with regard to initial HPV viral load.
conclusionLow initial HPV viral load may be a poor prognostic factor for cervical cancer patients who have undergone radical hysterectomy.
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