Evidence map›Paper›PMID 25872788›Full record

ArticleCirculation. Heart failure2015

Alcohol and incident heart failure among middle-aged and elderly men: cohort of Swedish men.

Kirsten S Dorans, Elizabeth Mostofsky, Emily B Levitan, Niclas Håkansson, Alicja Wolk, Murray A Mittleman

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. The Link between Alcohol Consumption and Kidney Injury.The American journal of pathology · 2026
    Review
  3. Article
  4. Review
  5. Alcoholic cardiomyopathy: an update.European heart journal · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Alcohol and Heart Failure.European cardiology · 2023
    Review
  10. Changes in Alcohol Consumption and Risk of Heart Failure: A Nationwide Population-Based Study in Korea.International journal of environmental research and public health · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Alcohol and Cardiovascular Disease: How Much is Too Much?Current atherosclerosis reports · 2017
    Review
  15. Alcoholic Beverage Consumption and Chronic Diseases.International journal of environmental research and public health · 2016
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kirsten S DoransFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.).
Elizabeth MostofskyFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.).
Emily B LevitanFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.).
Niclas HåkanssonFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.).
Alicja WolkFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.).
Murray A MittlemanFrom the Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, Harvard School of Public Health, Boston, MA (K.S.D., E.M., M.A.M.); Department of Epidemiology, University of Alabama at Birmingham (E.B.L.); and Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (N.H., A.W.). mmittlem@bidmc.harvard.edu.
Harvard University · USUniversity of Alabama at Birmingham · US

Funding

Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Training Program in the Epidemiology of CVDT32HL007575 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURING, JULIE E., RIDKER, PAUL M. · 1985 to 2019
$5.0M
Bereavement and Cardiovascular Events: A Nationwide Prospective Study in SwedenF32HL120505 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSTOFSKY, ELIZABETH · 2013 to 2013
$54k
NCATS NIH HHS KL2 TR001100NHLBI NIH HHS F32 HL120505NHLBI NIH HHS HL-115623NHLBI NIH HHS HL-120505NHLBI NIH HHS L30 HL115623NHLBI NIH HHS T32 HL007575
6 · The paper itself

Abstract

backgroundCompared with no alcohol consumption, heavy alcohol intake is associated with a higher rate of heart failure (HF) whereas light-to-moderate intake may be associated with a lower rate. However, several prior studies did not exclude former drinkers, who may have changed alcohol consumption in response to diagnosis. This study aimed to investigate the association between alcohol intake and incident HF. METHODS AND

resultsWe conducted a prospective cohort study of 33 760 men aged 45 to 79 years with no HF, diabetes mellitus, or myocardial infarction at baseline participating in the Cohort of Swedish Men Study. We excluded former drinkers. At baseline, participants completed a food frequency questionnaire and reported other characteristics. HF was defined as hospitalization for or death from HF, ascertained by Swedish inpatient and cause-of-death records from January 1, 1998, through December 31, 2011. We constructed Cox proportional hazards models to estimate multivariable-adjusted incidence rate ratios. During follow-up, 2916 men were hospitalized for (n=2139) or died (n=777) of incident HF. There was a U-shaped relationship between total alcohol intake and incident HF (P=0.0004). There was a nadir at light-to-moderate alcohol intake: consuming 7 to <14 standard drinks per week was associated with a 19% lower multivariable-adjusted rate of HF compared with never drinking (incidence rate ratio, 0.81; 95% confidence interval, 0.69-0.96).

conclusionsIn this cohort of Swedish men, there was a U-shaped relationship between alcohol consumption and HF incidence, with a nadir at light-to-moderate intake. Heavy intake did not seem protective.

Indexed as

AgedAge FactorsAlcohol DrinkingCause of DeathHeart FailureHospitalizationHumansIncidenceMaleMarkov ChainsMiddle AgedMonte Carlo MethodMultivariate AnalysisProportional Hazards ModelsProspective StudiesProtective Factorsalcohol consumptioncohort studiesepidemiologyheart failure

Identifiers

PMID25872788
PMCPMC4511919
OpenAlexW2015040332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.