ArticleBMC infectious diseases2015
Effectiveness of rotavirus vaccines, licensed but not funded, against rotavirus hospitalizations in the Valencia Region, Spain.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Seroepidemiology of Human Non-Species A Rotavirus Infections in Valencia, Spain.Journal of medical virology · 2025Article
- Effectiveness of self-financed rotavirus vaccines on acute gastroenteritis primary care episodes using real-world data in Spain: a propensity score-matched analysis of cohort study.European journal of pediatrics · 2024Article
- The Economic Value of Rotavirus Vaccination When Optimally Implemented in a High-Income Country.Vaccines · 2023Article
- Effectiveness of rotavirus vaccine in the prevention of diarrhoeal diseases among children under age five years in Kavango East and West Regions, Namibia.Journal of public health in Africa · 2021Article
- Impact of self-financed rotavirus vaccination on acute gastroenteritis in young children in Turkey.Human vaccines & immunotherapeutics · 2021Article
- Herpes zoster risk and burden of disease in immunocompromised populations: a population-based study using health system integrated databases, 2009-2014.BMC infectious diseases · 2020Article
- Spatio-temporal impact of self-financed rotavirus vaccination on rotavirus and acute gastroenteritis hospitalisations in the Valencia region, Spain.BMC infectious diseases · 2020Article
- Data Resource Profile: The Valencia Health System Integrated Database (VID).International journal of epidemiology · 2020Article
- Epidemiology of schizophrenia and its management over 8-years period using real-world data in Spain.BMC psychiatry · 2020Article
- Rotavirus symptomatic infection among unvaccinated and vaccinated children in Valencia, Spain.BMC infectious diseases · 2019Article
- Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain.International journal of environmental research and public health · 2019Article
- Effectiveness of the Oral Human Attenuated Rotavirus Vaccine: A Systematic Review and Meta-analysis-2006-2016.Open forum infectious diseases · 2018Review
- Lack of impact of rotavirus vaccines on seizure-related hospitalizations in children under 5 years old in Spain.Human vaccines & immunotherapeutics · 2018Article
- Effectiveness of rotavirus vaccines against hospitalisations in Japan.BMC pediatrics · 2017Article
- Long-term impact of self-financed rotavirus vaccines on rotavirus-associated hospitalizations and costs in the Valencia Region, Spain.BMC infectious diseases · 2017Article
- Determinants of seasonal influenza vaccination in pregnant women in Valencia, Spain.BMC public health · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough rotavirus vaccines have been licensed in Spain for over 8 years, they are not funded by its public health systems. The analysis of their effectiveness in the Valencia Region could better inform decisions about potential inclusion in the official immunization schedule. Our aim was to assess the effectiveness of Rotarix® (RV1) and RotaTeq® (RV5) against rotavirus hospitalizations.
methodsWe conducted a retrospective cohort study using the region's health care databases, among resident children aged <3 years covered by the National Health System, during January 2007-June 2012. We compared two cohorts of vaccinated children: the first included children who received at least one dose of a rotavirus vaccine, and the second included children who were not vaccinated with rotavirus vaccines but received at least one dose of a pneumococcal vaccine, another licensed but non-funded vaccine. The main outcome was rotavirus hospitalization, either laboratory-confirmed (confirmed) or codified as rotavirus (probable). Rotavirus vaccine effectiveness (RVE) by vaccine brand was assessed using Cox proportional hazards models.
resultsThe study included 78,281 rotavirus and 96,643 pneumococcal vaccinees. Adjusted RVE against probable or confirmed rotavirus hospitalizations was 86% (95% CI: 78-91%) and 88% (95% CI: 81-92%) for a complete series of RV1 and RV5 respectively.
conclusionsBoth rotavirus vaccines were over 85% effective against rotavirus hospitalization among young children. The high effectiveness shown argues in favor of their inclusion in the official schedule. Additional information on rotavirus vaccine safety, duration of protection, and benefit-risk will also be needed to inform such deliberations.
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