Trial reportTrials2015
Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sustained Aeration of Infant Lungs Trial
Non-inflatable Supraglottic Airway (NI-SGA) vs. Face Mask (FM) as a Primary Interface Device for Neonatal Resuscitation: A Pilot Study
Who cites it
19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2025Pooled it
- Sustained Inflation vs Standard Resuscitation for Preterm Infants: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2020Pooled it
- Sustained inflations and avoiding mechanical ventilation to prevent death or bronchopulmonary dysplasia: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2018Pooled it
- Sustained versus standard inflations during neonatal resuscitation to prevent mortality and improve respiratory outcomes.The Cochrane database of systematic reviews · 2017Pooled it
- Alternative consent processes in a neonatal resuscitation trial (SAIL): secondary analysis of an open-label, international, multicentre, randomised trial.The Lancet. Child & adolescent health · 2025Trial
- Trial
- Aeration strategy at birth does not impact carotid haemodynamics in preterm lambs.Pediatric research · 2023Article
- Current insights in non-invasive ventilation for the treatment of neonatal respiratory disease.Italian journal of pediatrics · 2019Review
- Key paediatric messages from the 2018 European Respiratory Society International Congress.ERJ open research · 2019Article
- Quality Improvement Project to Decrease Delivery Room Intubations in Preterm Infants.Pediatrics · 2019Article
- Chest Compressions in the Delivery Room.Children (Basel, Switzerland) · 2019Review
- Considering the Validity of the SAIL Trial-A Navel Gazers Guide to the SAIL Trial.Frontiers in pediatrics · 2019Article
- Effective ventilation: The most critical intervention for successful delivery room resuscitation.Seminars in fetal & neonatal medicine · 2018Review
- Preventing Continuous Positive Airway Pressure Failure: Evidence-Based and Physiologically Sound Practices from Delivery Room to the Neonatal Intensive Care Unit.Clinics in perinatology · 2018Review
- Delivery room interventions to prevent bronchopulmonary dysplasia in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2017Review
- Achieving and maintaining lung volume in the preterm infant: from the first breath to the NICU.European journal of pediatrics · 2017Review
- Resuscitation of extremely preterm infants - controversies and current evidence.World journal of clinical pediatrics · 2016Review
- Oxygen Supplementation to Stabilize Preterm Infants in the Fetal to Neonatal Transition: No Satisfactory Answer.Frontiers in pediatrics · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
Abstract
backgroundExtremely preterm infants require assistance recruiting the lung to establish a functional residual capacity after birth. Sustained inflation (SI) combined with positive end expiratory pressure (PEEP) may be a superior method of aerating the lung compared with intermittent positive pressure ventilation (IPPV) with PEEP in extremely preterm infants. The Sustained Aeration of Infant Lungs (SAIL) trial was designed to study this question. METHODS/
designThis multisite prospective randomized controlled unblinded trial will recruit 600 infants of 23 to 26 weeks gestational age who require respiratory support at birth. Infants in both arms will be treated with PEEP 5 to 7 cm H2O throughout the resuscitation. The study intervention consists of performing an initial SI (20 cm H20 for 15 seconds) followed by a second SI (25 cm H2O for 15 seconds), and then PEEP with or without IPPV, as needed. The control group will be treated with initial IPPV with PEEP. The primary outcome is the combined endpoint of bronchopulmonary dysplasia or death at 36 weeks post-menstrual age.
trial registrationwww.clinicaltrials.gov , Trial identifier NCT02139800 , Registered 13 May 2014.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.