Evidence map›Paper›PMID 25872508›Full record

ArticleCirculation. Cardiovascular quality and outcomes2015

Association between divorce and risks for acute myocardial infarction.

Matthew E Dupre, Linda K George, Guangya Liu, Eric D Peterson

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
39.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Marital Failure and Subsequent Heart Failure: A Prospective Study.Journal of the American Heart Association · 2025
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  12. Marital Loss and Cognitive Function: Does Timing Matter?The journals of gerontology. Series B, Psychological sciences and social sciences · 2022
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  18. Immune Mechanisms of Plaque Instability.Frontiers in cardiovascular medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew E DupreFrom the Duke Clinical Research Institute (M.E.D., E.D.P.), Department of Community and Family Medicine (M.E.D.), Department of Sociology (M.E.D., L.K.G.), Duke Law School (G.L.), and Division of Cardiology, Department of Medicine, Duke University Medical Center (E.D.P.), Duke University, Durham, NC. matthew.dupre@dm.duke.edu.
Linda K GeorgeFrom the Duke Clinical Research Institute (M.E.D., E.D.P.), Department of Community and Family Medicine (M.E.D.), Department of Sociology (M.E.D., L.K.G.), Duke Law School (G.L.), and Division of Cardiology, Department of Medicine, Duke University Medical Center (E.D.P.), Duke University, Durham, NC.
Guangya LiuFrom the Duke Clinical Research Institute (M.E.D., E.D.P.), Department of Community and Family Medicine (M.E.D.), Department of Sociology (M.E.D., L.K.G.), Duke Law School (G.L.), and Division of Cardiology, Department of Medicine, Duke University Medical Center (E.D.P.), Duke University, Durham, NC.
Eric D PetersonFrom the Duke Clinical Research Institute (M.E.D., E.D.P.), Department of Community and Family Medicine (M.E.D.), Department of Sociology (M.E.D., L.K.G.), Duke Law School (G.L.), and Division of Cardiology, Department of Medicine, Duke University Medical Center (E.D.P.), Duke University, Durham, NC.
Duke University · US

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI Tyson Brown · 2009 to 2026
$12.2M
Using Data to Drive Change in National CV Care: The Duke CERTSU19HS021092 · AHRQ · DUKE UNIVERSITY · PI PETERSON, ERIC DAVID · 2011 to 2015
$4.2M
Centers for Cardiovascular Outcomes ResearchU01HL107023 · NHLBI · DUKE UNIVERSITY · PI PETERSON, ERIC DAVID · 2010 to 2013
$2.6M
An Innovative Model to Predict Readmissions in Adults with Cardiovascular DiseaseK01HL114750 · NHLBI · DUKE UNIVERSITY · PI DUPRE, MATTHEW E. · 2013 to 2017
$590k
Marital Trajectories and Cardiovascular Disease in the United StatesR03AG042712 · NIA · DUKE UNIVERSITY · PI DUPRE, MATTHEW E. · 2013 to 2014
$157k
AHRQ HHS U19 HS021092NHLBI NIH HHS K01 HL114750NHLBI NIH HHS U01 HL107023NIA NIH HHS P30 AG034424NIA NIH HHS R03 AG042712NIA NIH HHS R03AG042712
6 · The paper itself

Abstract

backgroundDivorce is a major life stressor that can have economic, emotional, and physical health consequences. However, the cumulative association between divorce and risks for acute myocardial infarction (AMI) is unknown. This study investigated the association between lifetime exposure to divorce and the incidence of AMI in US adults. METHODS AND

resultsWe used nationally representative data from a prospective cohort of ever-married adults aged 45 to 80 years (n=15,827) who were followed biennially from 1992 to 2010. Approximately 14% of men and 19% of women were divorced at baseline and more than one third of the cohort had ≥1 divorce in their lifetime. In 200,524 person-years of follow-up, 8% (n=1211) of the cohort had an AMI and age-specific rates of AMI were consistently higher in those who were divorced compared with those who were continuously married (P<0.05). Results from competing-risk hazard models showed that AMI risks were significantly higher in women who had 1 divorce (hazard ratio, 1.24; 95% confidence interval, 1.01-1.55), ≥2 divorces (hazard ratio, 1.77; 95% confidence interval, 1.30-2.41), and among the remarried (hazard ratio, 1.35; 95% confidence interval, 1.07-1.70) compared with continuously married women after adjusting for multiple risk factors. Multivariable-adjusted risks were elevated only in men with a history of ≥2 divorces (hazard ratio, 1.30; 95% confidence interval, 1.02-1.66) compared with continuously married men. Men who remarried had no significant risk for AMI. Interaction terms for sex were not statistically significant.

conclusionsDivorce is a significant risk factor for AMI. The risks associated with multiple divorces are especially high in women and are not reduced with remarriage.

Indexed as

DivorceAgedAged, 80 and overCohort StudiesFemaleHumansIncidenceMaleMiddle AgedMyocardial InfarctionRisk FactorsSex FactorsStress, PsychologicalUnited Statesdivorcemyocardial infarctionsociological factors

Identifiers

PMID25872508
PMCPMC4439317
OpenAlexW2117842875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.