ArticleCancer2015
Effect of treatment and mammography detection on breast cancer survival over time: 1990-2007.
Article in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Pooled it
- Optimizing mobile mammography deployment in Oklahoma 2024: a two-step floating catchment area approach.Geospatial health · 2026Article
- The prevalence of mild cognitive impairment in breast cancer patients receiving chemotherapy according to the criteria of the National Institute on Aging-Alzheimer's Association (NIA-AA).Journal of cancer survivorship : research and practice · 2025Article
- Estimated health outcomes of breast cancer screening in the national breast and cervical cancer early detection program by race/ethnicity.Cancer causes & control : CCC · 2025Article
- Multi-transcriptomics predicts clinical outcome in systemically untreated breast cancer patients with extensive follow-up.Breast cancer research : BCR · 2025Article
- Article
- An insight into the role of innate immune cells in breast tumor microenvironment.Breast cancer (Tokyo, Japan) · 2025Review
- Dense breast tissue in screened postmenopausal women: Prevalence and determinants.Saudi medical journal · 2024Article
- Prognostic Factors Associated with Breast Cancer-Specific Survival from 1995 to 2022: A Systematic Review and Meta-Analysis of 1,386,663 Cases from 30 Countries.Diseases (Basel, Switzerland) · 2024Review
- The effect of radiotherapy on patients with pathological stage IIB breast cancer after breast-conserving surgery or mastectomy: A cohort study.Journal of the Chinese Medical Association : JCMA · 2024Article
- Breast cancer outcomes based on method of detection in community-based breast cancer registry.Breast cancer research and treatment · 2024Article
- Increased breast cancer mortality due to treatment delay and needle biopsy type: a retrospective analysis of SEER-medicare.Breast cancer (Tokyo, Japan) · 2023Article
- Characteristics of breast cancers detected by screening mammography in Taiwan: a single institute's experience.BMC women's health · 2023Article
- Survival in male breast cancer over the past 3 decades.Journal of the National Cancer Institute · 2023Article
- Self-detection remains a primary means of breast cancer detection in Beijing, China.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2023Article
- Artificial Intelligence for Breast Cancer Screening in Mammography (AI-STREAM): A Prospective Multicenter Study Design in Korea Using AI-Based CADe/x.Journal of breast cancer · 2022Article
- Effect of mammography screening on the long-term survival of breast cancer patients: results from the National Cancer Screening Program in Korea.Epidemiology and health · 2022Article
- Tumor stiffness measured by shear-wave elastography: association with disease-free survival in women with early-stage breast cancer.The British journal of radiology · 2021Article
- Worry and rumination in breast cancer patients: perseveration worsens self-rated health.Journal of behavioral medicine · 2021Article
- An Improved Stress-Scale Specifically Designed to Measure Stress of Women with Newly Diagnosed Breast Cancer.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe extent to which improvements over time in breast cancer survival are related to earlier detection by mammography or to more effective treatments is not known.
methodsAt a comprehensive cancer care center, the authors conducted a retrospective cohort study of women ages 50 to 69 years who were diagnosed with invasive breast cancer (stages I through III) and were followed over 3 periods (1990-1994, 1995-1999, and 2000-2007). Data were abstracted from patient charts and included detection method, diagnosis, treatment, and follow-up for vital status in the institutional breast cancer registry (n = 2998). The method of detection was categorized as patient or physician detected or mammography detected. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for 5-year disease-specific survival in relation to detection method and treatment factors, and differences in survival were analyzed using the Kaplan-Meier method.
resultsFifty-eight percent of breast cancers were mammography detected, and 42% were patient or physician detected; 56% of tumors were stage I, 31% were stage II, and 13% were stage III. The average length of follow-up was 10.71 years. The combined 5-year disease-specific survival rate was 89% from 1990 to 1994, 94% from 1995 to 1999, and 96% from 2000 to 2007 (P < .001). In an adjusted model, mammography detection (HR, 0.43; 95% CI, 0.27-0.70), hormone therapy (HR, 0.47; 95% CI, 0.30-0.75), and taxane-containing chemotherapy (HR, 0.61; 95% CI, 0.37-0.99) were significantly associated with a decreased risk of disease-specific mortality.
conclusionsBetter breast cancer survival over time was related to mammography detection, hormone therapy, and taxane-containing chemotherapy. Treatment improvements alone are not sufficient to explain the observed survival improvements over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.