ArticleOptics letters2015
Bone assessment via thermal photo-acoustic measurements.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Development of a semi-anthropomorphic photoacoustic calcaneus phantom based on nano computed tomography and stereolithography 3D printing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Theoretical and experimental study of attenuation in cancellous bone.Journal of biomedical optics · 2024Article
- Quick identification of prostate cancer by wavelet transform-based photoacoustic power spectrum analysis.Photoacoustics · 2022Article
- Characterization of multi-biomarkers for bone health assessment based on photoacoustic physicochemical analysis method.Photoacoustics · 2022Article
- Piezoelectric and Opto-Acoustic Material Properties of Bone.Advances in experimental medicine and biology · 2022Article
- Detection of collagen by multi-wavelength photoacoustic analysis as a biomarker for bone health assessment.Photoacoustics · 2021Article
- The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bonePhotoacoustics · 2021Article
- Wavelet transform-based photoacoustic time-frequency spectral analysis for bone assessment.Photoacoustics · 2021Article
- Towards Clinical Translation of LED-Based Photoacoustic Imaging: A Review.Sensors (Basel, Switzerland) · 2020Review
- Functional Photoacoustic and Ultrasonic Assessment of Osteoporosis: A Clinical Feasibility Study.BME frontiers · 2020Article
- Changing landscape of optical imaging in skeletal metastases.Journal of bone oncology · 2019Review
- Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes.Journal of visualized experiments : JoVE · 2018Article
- Noninvasive chorioretinal imaging in living rabbits using integrated photoacoustic microscopy and optical coherence tomography.Optics express · 2017Article
- Non-Contact Photoacoustic Imaging Using a Commercial Heterodyne Interferometer.IEEE sensors journal · 2016Article
- Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent.Scientific reports · 2016Article
- Characterization of bone microstructure using photoacoustic spectrum analysis.Optics express · 2015Article
- Integrated photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for multimodal chorioretinal imaging.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Retinal and choroidal imagingProceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The feasibility of an innovative biomedical diagnostic technique, thermal photo-acoustic (TPA) measurement, for non-ionizing and non-invasive assessment of bone health is investigated. Unlike conventional photo-acoustic PA methods that are mostly focused on the measurement of absolute signal intensity, TPA targets the change in PA signal intensity as a function of the sample temperature, i.e., the temperature-dependent Grueneisen parameter that is closely relevant to the chemical and molecular properties in the sample. Based on the differentiation measurement, the results from TPA technique are less susceptible to the variations associated with sample and system, and could be quantified with improved accurately. Due to the fact that the PA signal intensity from organic components such as blood changes faster than that from non-organic mineral under the same modulation of temperature, TPA measurement is able to objectively evaluate bone mineral density (BMD) and its loss as a result of osteoporosis. In an experiment on well-established rat models of bone loss and preservation, PA measurements of rat tibia bones were conducted over a temperature range from 37°C to 44°C. The slope of PA signal intensity verses temperature was quantified for each specimen. The comparison among three groups of specimens with different BMD shows that bones with lower BMD have higher slopes, demonstrating the potential of the proposed TPA technique in future clinical management of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.