Trial reportTrials2015
Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet Study): study protocol for a randomized controlled trial.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01516710 (Prospective Randomized Study of Laparoscopic Versus Open Liver Resection for Colorectal Metastases), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Randomized Study of Laparoscopic Versus Open Liver Resection for Colorectal Metastases
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of laparoscopic versus open liver resection for colorectal liver metastases.Oncotarget · 2016Pooled it
- Postoperative changes in body composition after laparoscopic and open resection of colorectal liver metastases: data from the randomized OSLO-COMET trial.Surgical endoscopy · 2025Trial
- Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases.Cancer biology & therapy · 2020Trial
- Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial.Medicine · 2015Trial
- Morphological changes on the human liver during minimally invasive surgery: Implications for image-guided interventions and surgical navigation.Surgical endoscopy · 2026Article
- Robotic liver parenchymal transection techniques: a comprehensive overview and classification.Journal of robotic surgery · 2024Review
- Automated algorithm for medical data structuring, and segmentation using artificial intelligence within secured environment for dataset creation.European journal of radiology open · 2024Article
- Achievement of textbook outcome after hepatectomy combined with thermal ablation for colorectal liver metastases.Surgical endoscopy · 2024Article
- Is operation time over the benchmark value a risk factor for worse short-term outcomes after laparoscopic liver resection?Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Short- and Long-Term Outcomes in Elderly Patients Following Hand-Assisted Laparoscopic Surgery for Colorectal Liver Metastasis.Journal of clinical medicine · 2023Article
- ACancer research communications · 2023Article
- Learning deep abdominal CT registration through adaptive loss weighting and synthetic data generation.PloS one · 2023Article
- Generic surgical process model for minimally invasive liver treatment methods.Scientific reports · 2022Article
- Laparoscopic resection of hepatic alveolar echinococcosis: A single-center experience.PLoS neglected tropical diseases · 2022Article
- Survival Study: International Multicentric Minimally Invasive Liver Resection for Colorectal Liver Metastases (SIMMILR-2).Cancers · 2022Article
- Evolution of laparoscopic liver surgery: 20-year experience of a Norwegian high-volume referral center.Surgical endoscopy · 2022Article
- Evaluation of clinical applicability of automated liver parenchyma segmentation of multi-center magnetic resonance images.European journal of radiology open · 2022Article
- Laparoscopic Liver Resection Using a Silicone Band Retraction Method (With Video).Surgical laparoscopy, endoscopy & percutaneous techniques · 2021Article
- Comparison and validation of three difficulty scoring systems in laparoscopic liver surgery: a retrospective analysis on 300 cases.Surgical endoscopy · 2020Article
- Anatomical Versus Nonanatomical Resection for Colorectal Liver Metastasis.World journal of surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaparoscopic liver resection is used in specialized centers all over the world. However, laparoscopic liver resection has never been compared with open liver resection in a prospective, randomized trial. METHODS/
designThe Oslo-CoMet Study is a randomized trial into laparoscopic versus open liver resection for the surgical management of hepatic colorectal metastases. The primary outcome is 30-day perioperative morbidity. Secondary outcomes include 5-year survival (overall, disease-free and recurrence-free), resection margins, recurrence pattern, postoperative pain, health-related quality of life, and evaluation of the inflammatory response. A cost-utility analysis of replacing open surgery with laparoscopic surgery will also be performed. The study includes all resections for colorectal liver metastases, except formal hemihepatectomies, resections where reconstruction of vessels/bile ducts is necessary and resections that need to be combined with ablation. All patients will participate in an enhanced recovery after surgery program. A biobank of liver and tumor tissue will be established and molecular analysis will be performed. DISCUSSION: After 35 months of recruitment, 200 patients have been included in the trial. Molecular and immunology data are being analyzed. Results for primary and secondary outcome measures will be presented following the conclusion of the study (late 2015). The Oslo-CoMet Study will provide the first level 1 evidence on the benefits of laparoscopic liver resection for colorectal liver metastases.
trial registrationThe trial was registered in ClinicalTrals.gov (NCT01516710) on 19 January 2012.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.