Evidence map›Paper›PMID 25872006›Full record

ArticleEndocrinology2015

Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling.

Kimberly A Russo, Janet L La, Shannon B Z Stephens, Matthew C Poling, Namita A Padgaonkar, Kimberly J Jennings, David J Piekarski, Alexander S Kauffman, Lance J Kriegsfeld

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
11.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 66 citations in OpenAlex.

  1. Circadian Behavioral and Bioluminescence Rhythms in theJournal of biological rhythms · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kimberly A RussoDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Janet L LaDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Shannon B Z StephensDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Matthew C PolingDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Namita A PadgaonkarDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Kimberly J JenningsDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
David J PiekarskiDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Alexander S KauffmanDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
Lance J KriegsfeldDepartment of Psychology (K.A.R., J.L.L., N.A.P., K.J.J., D.J.P., L.J.K.) and The Helen Wills Neuroscience Institute (L.J.K.), University of California, Berkeley, Berkeley, California 94720; and Department of Reproductive Medicine (S.B.Z.S., M.C.P., A.S.K.), University of California, San Diego, La Jolla, California 92093.
University of California, Berkeley · USUniversity of California, San Diego · US

Funding

The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1985 to 2020
$7.5M
The role of kisspeptin and RFRP-3 in the neuroendocrine control of female reproductionR01HD050470 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRIEGSFELD, LANCE J · 2007 to 2022
$5.0M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
NICHD NIH HHS P50 HD012303NICHD NIH HHS R01 HD-050470NICHD NIH HHS R01 HD050470NICHD NIH HHS T32 HD007203
6 · The paper itself

Abstract

Throughout most of the ovulatory cycle, estrogen negative feedback restrains the GnRH neuronal system. Just before ovulation, however, estrogen negative feedback is removed to permit stimulation of the preovulatory GnRH/LH surge (positive feedback) by the circadian clock in the suprachiasmatic nucleus (SCN). The mammalian ortholog of avian gonadotropin-inhibitory hormone, RFamide-related peptide 3 (RFRP-3), participates in the circadian-timed removal of estrogen negative feedback to permit the LH surge. The present study examined the specific neurochemical means by which the SCN controls RFRP-3 activity and explored whether the RFRP-3 system exhibits time-dependent responsiveness to SCN signaling to precisely time the LH surge. We found that RFRP-3 cells in female Syrian hamsters (Mesocricetus auratus) receive close appositions from SCN-derived vasopressin-ergic and vasoactive intestinal peptide (VIP)-ergic terminal fibers. Central VIP administration markedly suppressed RFRP-3 cellular activity in the evening, but not the morning, relative to saline controls, whereas vasopressin was without effect at either time point. Double-label in situ hybridization for Rfrp-3 and the VIP receptors VPAC1 and VPAC2 revealed that the majority of RFRP-3 cells do not coexpress either receptor in Syrian hamsters or mice, suggesting that SCN VIP-ergic signaling inhibits RFRP-3 cells indirectly. The timing of this VIP-mediated disinhibition is further coordinated via temporally gated responsiveness of RFRP-3 cells to circadian signaling. Together, these findings reveal a novel circadian hierarchy of control coordinating the preovulatory LH surge and ovulation.

Indexed as

Circadian ClocksAnimalsCircadian RhythmCricetinaeEstrous CycleFemaleGonadotropin-Releasing HormoneLuteinizing HormoneMesocricetusNeuronsNeuropeptidesOvulationReceptors, Vasoactive Intestinal Peptide, Type IIReceptors, Vasoactive Intestinal Polypeptide, Type ISignal TransductionSuprachiasmatic NucleusGonadotropin-Releasing HormoneLuteinizing HormoneNeuropeptidesReceptors, Vasoactive Intestinal Peptide, Type IIReceptors, Vasoactive Intestinal Polypeptide, Type IRFamide peptideVasoactive Intestinal PeptideVasopressins

Identifiers

PMID25872006
PMCPMC4475714
OpenAlexW2105250661

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.