Evidence map›Paper›PMID 25871976›Full record

ArticleTranslational psychiatry2015

Novel insights into the behavioral analysis of mice subjected to the forced-swim test.

L Chen, G C Faas, I Ferando, I Mody

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

L Chen1] Molecular, Cellular and Integrative Physiology Interdepartmental Ph.D. Program, University of California Los Angeles, Los Angeles, CA, USA [2] Department of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
G C FaasDepartment of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
I FerandoDepartment of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.
I Mody1] Department of Neurology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA [2] Department of Physiology, The David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA, USA.

Funding

ENDOGENOUS GABAERGIC ACTIVITY IN THE MAMMALIAN BRAINR01NS030549 · NINDS · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI MODY, ISTVAN · 1992 to 2018
$4.5M
Endogenous GABAergic ActivityR37NS030549 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODY, ISTVAN · 2001 to 2007
$2.7M
Regulations of Neurotransmitter Action by Steroid Hormones in FemalesR01MH076994 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODY, ISTVAN · 2007 to 2011
$1.6M
NIMH NIH HHS MH076994NIMH NIH HHS R01 MH076994NINDS NIH HHS NS030549NINDS NIH HHS R01 NS030549NINDS NIH HHS R37 NS030549
6 · The paper itself

Abstract

The forced-swim test (FST) is one of the most widely used rodent behavioral assays, in which the immobility of animals is used to assess the effectiveness of antidepressant drugs. However, the existing, and mostly arbitrary, criteria used for quantification could lead to biased results. Here we believe we uncovered new confounding factors, revealed new indices to interpret the behavior of mice and propose an unbiased means for quantification of the FST.

Indexed as

Behavior, AnimalDisease Models, AnimalMajor Depressive DisorderMotor ActivitySwimmingAnimalsCalbindin 1Confounding Factors, EpidemiologicFemaleHeterozygoteMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, GABA-ACalb1 protein, mouseCalbindin 1Gabra5 protein, mouseReceptors, GABA-A

Identifiers

PMID25871976
PMCPMC4462607

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.