Evidence map›Paper›PMID 25871869›Full record

ReviewJournal of infusion nursing : the official publication of the Infusion Nurses Society

Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?

Amy G Tsai, Beatriz Y Salazar Vázquez, Axel Hofmann, Seetharama A Acharya, Marcos Intaglietta

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of infusion nursing : the official publication of the Infusion Nurses Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Transfusion of Red Blood Cells to Patients with Sepsis.International journal of molecular sciences · 2017
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Amy G TsaiUniversity of California, San Diego, Department of Bioengineering, La Jolla, California (Drs Tsai, Salazar Vázquez, and Intaglietta); Universidad Nacional Autónoma de México, Hospital General de México "Dr. Eduardo Liceaga," Department of Experimental Medicine, México DF, México (Dr Salazar Vázquez); Universidad Juárez del Estado de Durango, Victoria de Durango, Faculty of Medicine, Dgo, Mexico (Dr Salazar Vázquez); University Hospital, Institute of Anesthesiology, Zürich, Switzerland (Dr Hofmann); University of Western Australia, School of Surgery, Perth, Australia (Dr Hofmann); and Albert Einstein College of Medicine, Department of Hematology and Medicine, Bronx, New York (Dr Acharya). Amy G. Tsai, PhD, is a research scientist and principal investigator in the Department of Bioengineering of the University of California, San Diego. She specializes in the study of in vivo microvascular responses to hemorrhagic shock and acute anemia, with the aim of developing new resuscitation fluids, next-generation plasma expanders, and oxygen carriers. Beatriz Y. Salazar Vázquez, MD, PhD, is a visiting scholar at the University of California, San Diego, and a research scientist at the Universidad Nacional Autónoma de México, where she studies the cardiovascular effects of hematocrit changes. Axel Hofmann, ME, is a visiting professor at the Institute of Anesthesiology at University Hospital in Zürich, Switzerland, and an adjunct associate professor in the School of Surgery at the University of Western Australia. Seetharama A. Acharya, PhD, is a professor of hematology and biophysics at the Albert Einstein College of Medicine in New York. He is an expert on protein peglylation design as applied to its use as blood replacement fluids. Marcos Intaglietta, PhD, is a distinguished professor of bioengineering at the University of California, San Diego, and is an authority in the analysis of the microcirculation and how it behaves during changes of blood composition resul
Beatriz Y Salazar Vázquez
Axel Hofmann
Seetharama A Acharya
Marcos Intaglietta
Basler & Hofmann (Switzerland) · CHCasa de Velázquez · ES

Funding

Recombinant HbAp Production for In Vivo Toxicity StudiesP01HL110900 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI FRIEDMAN, JOEL M · 2012 to 2016
$10.6M
NHLBI NIH HHS P01 HL110900
6 · The paper itself

Abstract

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.

Indexed as

AnemiaErythrocyte TransfusionHemorrhageHumansOxygenPlasma SubstitutesOxygenPlasma Substitutes

Identifiers

PMID25871869
PMCPMC5608479
OpenAlexW2006791223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.