ArticleJAMA2015
FDG-PET/CT imaging for mediastinal staging in patients with potentially resectable non-small cell lung cancer.
Article in JAMA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- High Diagnostic Accuracy and Safety of Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Malignant Lymph Nodes: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2021Pooled it
- Pooled it
- A novel technique for tumor localization and targeted lymphatic mapping in early-stage lung cancer.The Journal of thoracic and cardiovascular surgery · 2017Trial
- Review
- Machine Learning-Driven Radiomics for an Early-Stage Predictive Model of Nodal Upstaging in Thoracic Oncology.Cancers · 2026Article
- Development of PET/CT-clinical nomograms for predicting lymph node metastasis in primary lung cancer.European radiology · 2026Article
- PreoperativeTranslational lung cancer research · 2026Article
- Dynamic fluorine-18 fluorodeoxyglucose PET for evaluating different-sized metastatic lymph nodes in patients with non-small cell lung cancers.Quantitative imaging in medicine and surgery · 2026Article
- Current advances in mediastinal staging for non-small cell lung cancer: a narrative review.Translational lung cancer research · 2026Review
- Mediastinal staging of nonsmall cell lung cancer: what's new?Breathe (Sheffield, England) · 2025Review
- Predictive value of radiomics modeling based on dynamic and staticFrontiers in oncology · 2025Article
- The value of net influx constant based on FDG PET/CT dynamic imaging in the differential diagnosis of metastatic from non-metastatic lymph nodes in lung cancer.Annals of nuclear medicine · 2024Article
- Surgery versus radiotherapy in octogenarians with stage Ia non‑small cell lung cancer: propensity score matching analysis of the SEER database.BMC pulmonary medicine · 2022Article
- Using Natural Language Processing and Machine Learning to Preoperatively Predict Lymph Node Metastasis for Non-Small Cell Lung Cancer With Electronic Medical Records: Development and Validation Study.JMIR medical informatics · 2022Article
- Dynamic FDG-PET imaging for differentiating metastatic from non-metastatic lymph nodes of lung cancer.Frontiers in oncology · 2022Article
- Cone-Beam CT With Augmented Fluoroscopy Combined With Electromagnetic Navigation Bronchoscopy for Biopsy of Pulmonary Nodules.Journal of bronchology & interventional pulmonology · 2018Article
- Article
- Endobronchial ultrasound-guided transbronchial needle aspiration of hilar and mediastinal lymph nodes detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography.Japanese journal of clinical oncology · 2016Article
- [Analysis of the Role of PET/CT SUVmax in Prognosis and Its Correlation with Clinicopathological Characteristics in Resectable Lung Squamous Cell Carcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2016Article
- Early stage lung cancer with nodal involvement occult to PET-CT: treat the image or treat the disease?Journal of thoracic disease · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
clinical questionWhat is the sensitivity and specificity of 18F-fludeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) imaging for detecting mediastinal lymph node involvement in patients with potentially resectable non-small cell lung cancer (NSCLC)? BOTTOM LINE: Sensitivity and specificity of FDG-PET/CT imaging ranged from 0.77 to 0.81 for sensitivity and 0.79 to 0.90 for specificity, and were related to the brand of scanner, NSCLC subtype, FDG dose, and country of study origin. These sensitivities and specificities are not sufficiently accurate to warrant reliance on FDG-PET/CT scanning alone to make decisions about surgery as a single option for patients with potentially resectable NSCLC. Instead FDG-PET/CT imaging should be used to determine whether the next step should be biopsy (endobronchial ultrasound-guided biopsy or mediastinoscopy) or surgical resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.