ArticleActa biomaterialia2015
Biomimetic gradient scaffold from ice-templating for self-seeding of cells with capillary effect.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 117 citations in OpenAlex.
- A tree-inspired liquid-managing scaffold with radial-axial continuity for wound exudate management.Materials today. Bio · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Development of Biomimetic Edible Scaffolds for Cultured Meat Based on the Traditional Freeze-Drying Method forGels (Basel, Switzerland) · 2025Article
- Impact of Particle Size and Sintering Temperature on Calcium Phosphate Gyroid Structure Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2024Article
- Aligned Ice Templated Biomaterial Strategies for the Musculoskeletal System.Advanced healthcare materials · 2023Review
- Bone Tissue Engineering Scaffolds: Function of Multi-Material Hierarchically Structured Scaffolds.Advanced healthcare materials · 2023Review
- Non-Mulberry Silk Fiber-Based Composite Scaffolds Containing Millichannels for Auricular Cartilage Regeneration.ACS omega · 2022Article
- Patterned vascularization in a directional ice-templated scaffold of decellularized matrix.Engineering in life sciences · 2021Article
- Fabrication of chitosan-based electrospun nanofiber scaffold: Amplification of biomechanical properties, structural stability, and seeded cell viability.Veterinary research forum : an international quarterly journal · 2021Article
- 3D Printing of Layered Gradient Pore Structure of Brain-like Tissue.International journal of bioprinting · 2021Article
- Functionally graded biomaterials for use as model systems and replacement tissues.Advanced functional materials · 2020Article
- Osteointegration of 3D-Printed Fully Porous Polyetheretherketone Scaffolds with Different Pore Sizes.ACS omega · 2020Article
- 2D and 3D graphical datasets for bamboo-inspired tubular scaffolds with functional gradients: micrographs and tomograms.Data in brief · 2020Article
- [Biodegradation properties of multi-laminated small intestinal submucosa].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Digital Design and Automated Fabrication of Bespoke Collagen Microfiber Scaffolds.Tissue engineering. Part C, Methods · 2019Article
- Review
- Anisotropic freeze-cast collagen scaffolds for tissue regeneration: How processing conditions affect structure and properties in the dry and fully hydrated states.Journal of the mechanical behavior of biomedical materials · 2019Article
- Freeze-casting porous chitosan ureteral stents for improved drainage.Acta biomaterialia · 2019Article
- Characterization and Optimization of the Seeding Process of Adipose Stem Cells on the Polycaprolactone Scaffolds.Stem cells international · 2019Article
- Drug-Loaded Biomimetic Ceramics for Tissue Engineering.Pharmaceutics · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
One of the most important issues in bone tissue engineering is the search for new materials and processing techniques to create novel scaffolds with 3-D porous structures. Although many properties such as biodegradability and porosity have been considered in designing bone scaffolds, very limited attention is paid to their capillary effect. In nature, capillary effect is ubiquitously used by plants and animals to constantly transport water and nutrients based on morphological and/or chemical gradient structures at multiple length-scales. In this work, we developed a modified freeze-casting technique to prepare ceramic scaffolds with gradient channel structures. The results show that our hydroxyapatite (HA) scaffolds have interconnected gradient channels that mimic the porous network of natural bone. More importantly, we demonstrate that such a scaffold has a very unique capillary behavior that promotes the self-seeding of cells when in contact with a cell solution due to spontaneous capillary flow generated from gradient channel structures. The strategy developed here provides a new avenue for designing "smart" scaffolds with complex porous structures and biological functions that mimic natural tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.