Evidence map›Paper›PMID 25871496›Full record

Observational studyJournal of psychiatry & neuroscience : JPN2015

Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/ hyperactivity disorder.

Huey-Ling Chiang, Yu-Jen Chen, Yu-Chun Lo, Wen-Yih I Tseng, Susan S Gau

Open access · bronzeAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of psychiatry & neuroscience : JPN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Huey-Ling ChiangFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ( Chiang, Gau); Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (Chiang, Gau); Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan (Chiang); Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (Chen, Tseng, Lo); Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan (Tseng, Gau); Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (Tseng); Department of Psychology, School of Occupational Therapy, and Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Gau).
Yu-Jen ChenFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ( Chiang, Gau); Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (Chiang, Gau); Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan (Chiang); Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (Chen, Tseng, Lo); Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan (Tseng, Gau); Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (Tseng); Department of Psychology, School of Occupational Therapy, and Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Gau).
Yu-Chun LoFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ( Chiang, Gau); Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (Chiang, Gau); Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan (Chiang); Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (Chen, Tseng, Lo); Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan (Tseng, Gau); Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (Tseng); Department of Psychology, School of Occupational Therapy, and Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Gau).
Wen-Yih I TsengFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ( Chiang, Gau); Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (Chiang, Gau); Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan (Chiang); Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (Chen, Tseng, Lo); Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan (Tseng, Gau); Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (Tseng); Department of Psychology, School of Occupational Therapy, and Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Gau).
Susan S GauFrom the Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ( Chiang, Gau); Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan (Chiang, Gau); Department of Psychiatry, Far Eastern Memorial Hospital, Taipei, Taiwan (Chiang); Center for Optoelectronic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan (Chen, Tseng, Lo); Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan (Tseng, Gau); Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan (Tseng); Department of Psychology, School of Occupational Therapy, and Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan (Gau).
National Taiwan University · TWNational Taiwan University Hospital · TWFar Eastern Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe neural substrate for clinical symptoms and neuropsychological performance in individuals with attention-deficit/hyperactivity disorder (ADHD) has rarely been studied and has yielded inconsistent results. We sought to compare the microstructural property of fibre tracts associated with the prefrontal cortex and its association with ADHD symptoms and a wide range of attention performance in youth with ADHD and healthy controls.

methodsWe assessed youths with ADHD and age-, sex-, handedness-, coil- and intelligence-matched controls using the Conners' Continuous Performance Test (CCPT) for attention performance and MRI. The 10 target tracts, including the bilateral frontostriatal tracts (caudate to dorsolateral prefrontal cortex, ventrolateral prefrontal cortex and orbitofrontal cortex), superior longitudinal fasciculus (SLF) and cingulum bundle were reconstructed using diffusion spectrum imaging tractography. We computed generalized fractional anisotropy (GFA) values to indicate tract-specific microstructural property.

resultsWe included 50 youths with ADHD and 50 healthy controls in our study. Youths with ADHD had lower GFA in the left frontostriatal tracts, bilateral SLF and right cingulum bundle and performed worse in the CCPT than controls. Furthermore, alteration of the right SLF GFA was most significantly associated with the clinical symptom of inattention in youths with ADHD. Finally, youths with ADHD had differential association patterns of the 10 fibre tract GFA values with attention performance compared with controls. LIMITATIONS: Ten of the youths with ADHD were treated with methylphenidate, which may have long-term effects on microstructural property.

conclusionOur study highlights the importance of the SLF, cingulum bundle and frontostriatal tracts for clinical symptoms and attention performance in youths with ADHD and demonstrates the involvement of different fibre tracts in attention performance in these individuals.

Indexed as

AttentionAttention Deficit Disorder with HyperactivityCognitionImpulsive BehaviorNerve NetNeuroimagingPrefrontal CortexAdolescentCase-Control StudiesChildDopamine Uptake InhibitorsFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleDopamine Uptake InhibitorsMethylphenidate

Identifiers

PMID25871496
PMCPMC4543095
OpenAlexW2122837915

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.