Evidence map›Paper›PMID 25871291›Full record

ArticleMarine drugs2015

Antifungal compounds from cyanobacteria.

Tânia K Shishido, Anu Humisto, Jouni Jokela, Liwei Liu, Matti Wahlsten, Anisha Tamrakar, David P Fewer, Perttu Permi, Ana P D Andreote, Marli F Fiore and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. International journal of molecular sciences · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Plants (Basel, Switzerland) · 2024
    Article
  12. Antifungal peptides from living organisms.Frontiers in microbiology · 2024
    Review
  13. Article
  14. TheMolecules (Basel, Switzerland) · 2023
    Article
  15. Review
  16. Process Technologies of Cyanobacteria.Advances in biochemical engineering/biotechnology · 2023
    Article
  17. Article
  18. Heterologous production of cyanobacterial compounds.Journal of industrial microbiology & biotechnology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Tânia K ShishidoDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. tania.shishido@helsinki.fi.
Anu HumistoDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. anu.humisto@helsinki.fi.
Jouni JokelaDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. jouni.jokela@helsinki.fi.
Liwei LiuDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. liwei.liu@helsinki.fi.
Matti WahlstenDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. matti.wahlsten@helsinki.fi.
Anisha TamrakarDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. anisha.tamrakar@helsinki.fi.
David P FewerDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. david.fewer@helsinki.fi.
Perttu PermiProgram in Structural Biology and Biophysics, Institute of Biotechnology/Nuclear Magnetic Resonance Laboratory, University of Helsinki, FI-00014, Helsinki, Finland. perttu.permi@helsinki.fi.
Ana P D AndreoteCenter for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, Piracicaba, 13400-970, São Paulo, Brazil. apdini@cena.usp.br.
Marli F FioreCenter for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, Piracicaba, 13400-970, São Paulo, Brazil. fiore@cena.usp.br.
Kaarina SivonenDepartment of Food and Environmental Sciences, Viikki Biocenter 1, University of Helsinki, FI-00014, Helsinki, Finland. kaarina.sivonen@helsinki.fi.
University of Helsinki · FIUniversidade de São Paulo · BRBiocenter Finland · FIHelsinki Institute of Physics · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyanobacteria are photosynthetic prokaryotes found in a range of environments. They are infamous for the production of toxins, as well as bioactive compounds, which exhibit anticancer, antimicrobial and protease inhibition activities. Cyanobacteria produce a broad range of antifungals belonging to structural classes, such as peptides, polyketides and alkaloids. Here, we tested cyanobacteria from a wide variety of environments for antifungal activity. The potent antifungal macrolide scytophycin was detected in Anabaena sp. HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description of Anabaena strains that produce scytophycins. We detected antifungal glycolipopeptide hassallidin production in Anabaena spp. BIR JV1 and HAN7/1 and in Nostoc spp. 6sf Calc and CENA 219. These strains were isolated from brackish and freshwater samples collected in Brazil, the Czech Republic and Finland. In addition, three cyanobacterial strains, Fischerella sp. CENA 298, Scytonema hofmanni PCC 7110 and Nostoc sp. N107.3, produced unidentified antifungal compounds that warrant further characterization. Interestingly, all of the strains shown to produce antifungal compounds in this study belong to Nostocales or Stigonematales cyanobacterial orders.

Indexed as

Drug DiscoveryAnabaenaAntifungal AgentsAspergillus flavusBrazilCandida albicansCyanobacteriaCzech RepublicFinlandFresh WaterGlycolipidsLipopeptidesMolecular StructureMolecular TypingNostocPeptides, CyclicAntifungal AgentsGlycolipidsLipopeptidesPeptides, CyclicPyrans

Identifiers

PMID25871291
PMCPMC4413203
OpenAlexW1978011289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.