ArticleMarine drugs2015
Structural analysis and anticoagulant activities of the novel sulfated fucan possessing a regular well-defined repeating unit from sea cucumber.
Article in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 75 citations in OpenAlex.
- Marine sulfated glycan inhibits tau-heparan sulfate interaction and tau cellular uptake.International journal of biological macromolecules · 2026Article
- Suppressive Effects of an Inhibitor Composition on Skin Ulceration and Transcriptomic Analysis in the Sea CucumberBiology · 2026Article
- Analysis Methods and Structure-Activity Relationships of Polysaccharides in Sea Cucumber: A Review.Marine drugs · 2026Review
- Effects of Selenium, Iron, and Zinc Enrichment on Cultured Sea Cucumber (Apostichopus Japonicus).Biological trace element research · 2025Article
- The Sea CucumberJournal of natural products · 2023Article
- Fucose-Rich Sulfated Polysaccharides from Two Vietnamese Sea CucumbersMarine drugs · 2022Article
- A Fucan Sulfate with Pentasaccharide Repeating Units from the Sea CucumberMarine drugs · 2022Article
- Fucoidan for cardiovascular application and the factors mediating its activities.Carbohydrate polymers · 2021Review
- Comparison of Physicochemical Characteristics and Macrophage Immunostimulatory Activities of Polysaccharides fromMarine drugs · 2020Article
- Physicochemical Characteristics and Anticoagulant Activities of the Polysaccharides from Sea CucumberMarine drugs · 2019Article
- Antithrombotics from the Sea: Polysaccharides and Beyond.Marine drugs · 2019Review
- Structure and Anti-Inflammatory Activity of a New Unusual Fucosylated Chondroitin Sulfate fromMarine drugs · 2018Article
- Pharmacological Potential of Sea Cucumbers.International journal of molecular sciences · 2018Review
- Enzyme-Assisted Extraction Optimization, Characterization and Antioxidant Activity of Polysaccharides from Sea Cucumber Phyllophorus proteus.Molecules (Basel, Switzerland) · 2018Article
- Preliminary Characterization, Antioxidant and Hepatoprotective Activities of Polysaccharides from Taishan Pinus massoniana Pollen.Molecules (Basel, Switzerland) · 2018Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfated fucans, the complex polysaccharides, exhibit various biological activities. Herein, we purified two fucans from the sea cucumbers Holothuria edulis and Ludwigothurea grisea. Their structures were verified by means of HPGPC, FT-IR, GC-MS and NMR. As a result, a novel structural motif for this type of polymers is reported. The fucans have a unique structure composed of a central core of regular (1→2) and (1→3)-linked tetrasaccharide repeating units. Approximately 50% of the units from L. grisea (100% for H. edulis fucan) contain sides of oligosaccharides formed by nonsulfated fucose units linked to the O-4 position of the central core. Anticoagulant activity assays indicate that the sea cucumber fucans strongly inhibit human blood clotting through the intrinsic pathways of the coagulation cascade. Moreover, the mechanism of anticoagulant action of the fucans is selective inhibition of thrombin activity by heparin cofactor II. The distinctive tetrasaccharide repeating units contribute to the anticoagulant action. Additionally, unlike the fucans from marine alga, although the sea cucumber fucans have great molecular weights and affluent sulfates, they do not induce platelet aggregation. Overall, our results may be helpful in understanding the structure-function relationships of the well-defined polysaccharides from invertebrate as new types of safer anticoagulants.
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