SynthesisEnvironmental health perspectives2015
Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis.
Synthesis in Environmental health perspectives, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07383454 (Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model), which is not on this map. Cited by 115 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Cancer Screening in Population Who Had Never Smoked and the Validation of Lung Cancer Risk Prediction Model
Who cites it
115 citing papers in PubMed, 11 syntheses or guidelines pooled it, 419 citations in OpenAlex.
- Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis.Environmental health : a global access science source · 2025Pooled it
- Environmental risk factors, protective factors and lifestyles for lung cancer: an umbrella review.Frontiers in public health · 2025Pooled it
- Ambient air pollution and urological cancer risk: A systematic review and meta-analysis of epidemiological evidence.Nature communications · 2024Pooled it
- Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Assessing the Global Impact of Ambient Air Pollution on Cancer Incidence and Mortality: A Comprehensive Meta-Analysis.JCO global oncology · 2024Pooled it
- Adherence to Data-Driven Dietary Patterns and Lung Cancer Risk: A Systematic Review and Dose-Response Meta-Analysis.Nutrients · 2023Pooled it
- Neighborhood infrastructure-related risk factors and non-communicable diseases: a systematic meta-review.Environmental health : a global access science source · 2023Pooled it
- Challenges and recommendations on the conduct of systematic reviews of observational epidemiologic studies in environmental and occupational health.Journal of exposure science & environmental epidemiology · 2021Pooled it
- Systematic review and meta-analysis of cohort studies of long term outdoor nitrogen dioxide exposure and mortality.PloS one · 2021Pooled it
- Is breast cancer a result of epigenetic responses to traffic-related air pollution? A review of the latest evidence.Epigenomics · 2019Pooled it
- Long-term Concentrations of Nitrogen Dioxide and Mortality: A Meta-analysis of Cohort Studies.Epidemiology (Cambridge, Mass.) · 2018Pooled it
- Evaluating the Scale of Natural and Mechanical Airflows for Surface-Based Atmospheric Pollutant Removal.Environmental science & technology · 2026Article
- Au-Decorated WSSensors (Basel, Switzerland) · 2026Article
- Global disparities in lifetime risk of lung cancer: links to socioeconomic development, smoking, and fine particulate matter from GLOBOCAN 2022.Frontiers in public health · 2026Article
- European Code Against Cancer, 5th edition - outdoor and indoor air pollution and cancer.Molecular oncology · 2026Review
- Looking through the particles: a narrative review of air pollution and lung cancer.Journal of thoracic disease · 2025Review
- Assessment of Ambient Multipollutant Exposure and Health Impacts Over India Using the Novel Satellite-Based Multi-Pollutant Index.GeoHealth · 2025Article
- Global impact of air pollution on cancer: causal evidence and health inequities across regions from 1990 to 2021.BMC cancer · 2025Article
- Associations of light at night exposure and environmental pollutants with risk for thyroid cancer in Fujian, China: a spatio-temporal analysis.BMC public health · 2025Article
- Ambient air pollution exposure and lung cancer risk in a large prospective U.S. cohort.The Science of the total environment · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 5 countries.
Funding
Abstract
BACKGROUND AND
objectiveExposure to traffic-related air pollutants is an important public health issue. Here, we present a systematic review and meta-analysis of research examining the relationship of measures of nitrogen oxides (NOx) and of various measures of traffic-related air pollution exposure with lung cancer.
methodsWe conducted random-effects meta-analyses of studies examining exposure to nitrogen dioxide (NO2) and NOx and its association with lung cancer. We identified 20 studies that met inclusion criteria and provided information necessary to estimate the change in lung cancer per 10-μg/m3 increase in exposure to measured NO2. Further, we qualitatively assessed the evidence of association between distance to roadways and traffic volume associated with lung cancer.
resultsThe meta-estimate for the change in lung cancer associated with a 10-μg/m3 increase in exposure to NO2 was 4% (95% CI: 1%, 8%). The meta-estimate for change in lung cancer associated with a 10-μg/m3 increase in NOx was similar and slightly more precise, 3% (95% CI: 1%, 5%). The NO2 meta-estimate was robust to different confounding adjustment sets as well as the exposure assessment techniques used. Trim-and-fill analyses suggest that if publication bias exists, the overall meta-estimate is biased away from the null. Forest plots for measures of traffic volume and distance to roadways largely suggest a modest increase in lung cancer risk.
conclusionWe found consistent evidence of a relationship between NO2, as a proxy for traffic-sourced air pollution exposure, with lung cancer. Studies of lung cancer related to residential proximity to roadways and NOx also suggest increased risk, which may be attributable partly to air pollution exposure. The International Agency for Research on Cancer recently classified outdoor air pollution and particulate matter as carcinogenic (Group 1). These meta-analyses support this conclusion, drawing particular attention to traffic-sourced air pollution. CITATION: Hamra GB, Laden F, Cohen AJ, Raaschou-Nielsen O, Brauer M, Loomis D. 2015. Lung cancer and exposure to nitrogen dioxide and traffic: a systematic review and meta-analysis. Environ Health Perspect 123:1107-1112; http://dx.doi.org/10.1289/ehp.1408882.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.