ReviewPhysical chemistry chemical physics : PCCP2015
Dynamics and mechanisms of DNA repair by photolyase.
Review in Physical chemistry chemical physics : PCCP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA repair enzymes in sunscreens and their impact on photoageing-A systematic review.Photodermatology, photoimmunology & photomedicine · 2020Pooled it
- Fungal DNA damage repair: from model to driver of virulence and AMR.Bioscience reports · 2026Review
- Role of photolyase in stress tolerance and virulence of plant-pathogenic bacteriumApplied and environmental microbiology · 2026Article
- Transitioning enzyme catalysis towards photocatalysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Directed ultrafast conformational changes accompany electron transfer in a photolyase as resolved by serial crystallography.Nature chemistry · 2024Article
- Ultraviolet Radiation Biological and Medical Implications.Current issues in molecular biology · 2024Review
- Could violet-blue lights increase the bacteria resistance against ultraviolet radiation mediated by photolyases?Lasers in medical science · 2023Review
- A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome.Scientific reports · 2023Article
- An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms.Journal of fungi (Basel, Switzerland) · 2023Review
- Roles of DNA damage in renal tubular epithelial cells injury.Frontiers in physiology · 2023Review
- Application of 233 nm far-UVC LEDs for eradication of MRSA and MSSA and risk assessment on skin models.Scientific reports · 2022Article
- Article
- DNA photolyase from Antarctic marine bacterium3 Biotech · 2021Article
- Review
- Focus on UV-Induced DNA Damage and Repair-Disease Relevance and Protective Strategies.International journal of molecular sciences · 2020Review
- Theoretical insights into the DNA repair function ofBiophysics and physicobiology · 2020Article
- DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.Nucleic acids research · 2019Review
- DNA Damage Response Pathways in Dinoflagellates.Microorganisms · 2019Article
- Two divergent Symbiodinium genomes reveal conservation of a gene cluster for sunscreen biosynthesis and recently lost genes.BMC genomics · 2018Article
- A Compass at Weak Magnetic Fields Using Thymine Dimer Repair.ACS central science · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Photolyases, a class of flavoproteins, use blue light to repair two types of ultraviolet-induced DNA damage, a cyclobutane pyrimidine dimer (CPD) and a pyrimidine-pyrimidone (6-4) photoproduct (6-4PP). In this perspective, we review the recent progress in the repair dynamics and mechanisms of both types of DNA restoration by photolyases. We first report the spectroscopic characterization of flavin in various redox states and the active-site solvation dynamics in photolyases. We then systematically summarize the detailed repair dynamics of damaged DNA by photolyases and a biomimetic system through resolving all elementary steps on ultrafast timescales, including multiple intermolecular electron- and proton-transfer reactions and bond-breaking and -making processes. We determined the unique electron tunneling pathways, identified the key functional residues and revealed the molecular origin of high repair efficiency, and thus elucidate the molecular mechanisms and repair photocycles at the most fundamental level. We finally conclude that the active sites of photolyases, unlike the aqueous solution for the biomimetic system, provide a unique electrostatic environment and local flexibility and thus a dedicated synergy for all elementary dynamics to maximize the repair efficiency. This repair photomachine is the first enzyme that the entire functional evolution is completely mapped out in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.