Evidence map›Paper›PMID 25870787›Full record

ArticleMedical mycology case reports2015

Gastrointestinal cryptococcoma - Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?

Abdu K Musubire, David B Meya, Robert Lukande, Andrew Kambugu, Paul R Bohjanen, David R Boulware

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical mycology case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Distal jejunal obstruction due toMedical mycology case reports · 2022
    Article
  4. Review
  5. Article
  6. Gastric cryptococcosis: an unusual presentation of a common opportunistic disorder.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abdu K MusubireInfectious Disease Institute, College of health Sciences, Makerere University, Kampala, Uganda ; Department of Medicine, School of Medicine, College of Health Sciences, Makerere University and Mulago Hospital, Kampala, Uganda.
David B MeyaInfectious Disease Institute, College of health Sciences, Makerere University, Kampala, Uganda ; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA ; Department of Medicine, School of Medicine, College of Health Sciences, Makerere University and Mulago Hospital, Kampala, Uganda.
Robert LukandeDepartment of Pathology, College of Health Sciences, Makerere University, Kampala, Uganda.
Andrew KambuguInfectious Disease Institute, College of health Sciences, Makerere University, Kampala, Uganda ; Division of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Paul R BohjanenDivision of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
David R BoulwareDivision of Infectious Diseases & International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Funding

Trial for the Optimal Timing of HIV Therapy after Cryptococcal MeningitisU01AI089244 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R · 2010 to 2014
$7.6M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Outcomes of Cryptococcal Meningitis in UgandaK24AI096925 · NIAID · UNIVERSITY OF MINNESOTA · PI BOHJANEN, PAUL R · 2011 to 2015
$1.0M
Immune Reconstitution Syndrome in HIV infected Persons in Resource-Limited AreasK23AI073192 · NIAID · UNIVERSITY OF MINNESOTA · PI BOULWARE, DAVID R · 2009 to 2012
$530k
FIC NIH HHS R25 TW009345NIAID NIH HHS K23 AI073192NIAID NIH HHS K24 AI096925NIAID NIH HHS T32 AI055433NIAID NIH HHS U01 AI089244
6 · The paper itself

Abstract

The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present the case of an HIV-infected patient on ART, with a history of cryptococcal meningitis who presented with subacute, worsening abdominal pain during immune recovery. This evolved into chronic abdominal pain, with thickened bowel, and abdominal lymphadenopathy, while receiving empiric tuberculosis treatment. At 6-months, he developed intestinal perforation due to a histologically confirmed cryptococcoma.

Indexed as

AIDSAntiretroviral therapyCryptococcal meningitisCryptococcomaHIVImmune reconstitution inflammatory syndrome

Identifiers

PMID25870787
PMCPMC4389205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.